1.8.1.9: thioredoxin-disulfide reductase
This is an abbreviated version!
For detailed information about thioredoxin-disulfide reductase, go to the full flat file.
Word Map on EC 1.8.1.9
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1.8.1.9
-
selenium
-
selenoproteins
-
selenocysteine
-
gsh
-
peroxiredoxins
-
dismutase
-
catalase
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auranofin
-
glutaredoxins
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trx1
-
selenoenzyme
-
hydroperoxide
-
peroxidases
-
fad
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ribonucleotide
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redox-active
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cisplatin
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dithiols
-
goldi
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se-deficient
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dtnb
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iodothyronine
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flavoenzyme
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ebselen
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redox-sensitive
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selenium-containing
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selenols
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deiodinases
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thiol-dependent
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organoselenium
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thioredoxin-like
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selenium-deficient
-
se-dependent
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n-heterocyclic
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thioredoxin-dependent
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diselenide
-
redox-regulated
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selenium-dependent
-
thiol-disulfide
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thiol-based
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thioredoxin-1
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ask1
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carbene
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1-chloro-2,4-dinitrobenzene
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sulforaphane
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secis
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txnip
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trypanothione
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medicine
-
analysis
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na2seo3
-
agriculture
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thioredoxin-interacting
- 1.8.1.9
- selenium
-
selenoproteins
- selenocysteine
- gsh
- peroxiredoxins
- dismutase
- catalase
- auranofin
- glutaredoxins
- trx1
-
selenoenzyme
- hydroperoxide
- peroxidases
- fad
- ribonucleotide
-
redox-active
- cisplatin
- dithiols
-
goldi
-
se-deficient
- dtnb
-
iodothyronine
-
flavoenzyme
- ebselen
-
redox-sensitive
-
selenium-containing
-
selenols
-
deiodinases
-
thiol-dependent
-
organoselenium
-
thioredoxin-like
-
selenium-deficient
-
se-dependent
-
n-heterocyclic
-
thioredoxin-dependent
- diselenide
-
redox-regulated
-
selenium-dependent
-
thiol-disulfide
-
thiol-based
- thioredoxin-1
- ask1
-
carbene
- 1-chloro-2,4-dinitrobenzene
- sulforaphane
-
secis
-
txnip
- trypanothione
- medicine
- analysis
- na2seo3
- agriculture
-
thioredoxin-interacting
Reaction
Synonyms
all0737, ApTR, At2g41680, AtNTRA, AtNTRB, bacillithiol disulfide reductase, bacillithiol-disulfide reductase, BBOV_I002190, Bdr, BSSB reductase, CeTR2, DmTR, DmTrxR, DmTrxR-1, EC 1.6.4.5, EhTRXR, ferredoxin:thioredoxin reductase, FTR, general stress protein 35, GSP35, HCOI_01258400, hemolysate thioredoxin reductase, hemolysate TR, hTrxR, HvNTR1, HvNTR2, L-TR, L-TrxR, More, MtNTRC, mTR3, multifunctional thioredoxin-glutathione reductase, NAD(P)H:paraquat oxidoreductase, NADP-dependent thioredoxin reductase, NADP-linked thioredoxin reductase, NADP-thioredoxin reductase, NADP-thioredoxin reductase C, NADPH thioredoxin reductase, NADPH thioredoxin reductase C, NADPH-dependent thioredoxin reductase, NADPH-dependent thioredoxin reductase 2, NADPH-dependent thioredoxin reductase C, NADPH-dependent thioredoxin reductase I, NADPH-dependent thioredoxin reductase-1, NADPH-dependent TRX reductase, NADPH-thioredoxin reductase, NADPH-thioredoxin reductase C, NADPH-Trx reductase, NADPH2:oxidized thioredoxin oxidoreductase, NAPDH-dependent BSSB reductase, NTR, Ntr1, NTR2, Ntr3, NTRA, NTRAB, NtrB, NTRC, PH0178, PH1426, PhRP, PhTrxR, protein-disulfide oxidoreductase, reductase, thioredoxin, SEP1, taTrxR, TGR, thioredoxin glutathione reductase, thioredoxin h reductase, thioredoxin reductase, thioredoxin reductase (NADPH), thioredoxin reductase 1, thioredoxin reductase 2, thioredoxin reductase-1, thioredoxin reductase1, TON_1603, TR, TR1, TR2, TR3, TRase, TrR, Trr1, Trr1p, TRR2, Trx1, Trx3, TrxB, TrxB1, TrxB2, TrxR, TrxR-1(cyto), TrxR-1(mito), TrxR1, TrxR2, TrxR3, TrxRB3, TRXRD, TrxRh1, TrxRh2, TrxT, Txnrd1, TXNRD1-v3, Txnrd2, TXNRD3, TxrR-1, YpdA
ECTree
1.8.1.9 thioredoxin-disulfide reductaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.8.1.9 - thioredoxin-disulfide reductase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
NADPH + H+ + ubiquinone-10
NADP+ + ubiquinol-10
-
HEK cells overexpressing TrxR1 reduce ubiquinone-10
-
-
?
thioredoxin 1 + NADP+
thioredoxin 1 disulfide + NADPH + H+
-
TrxR2 prefers its endogenous substrate thioredocin 2 over thioredoxin 1 (10fold), whereas isoform TrxR1 efficiently reduces both thioredoxin 1 and thioredoxin 2
-
-
?
thioredoxin 1 + NADP+ +
thioredoxin 1 disulfide + NADPH + H+
-
-
-
-
?
thioredoxin 3 + NADP+
thioredoxin 3 disulfide + NADPH + H+
-
-
-
-
?
BrxA bacilliredoxin disulfide + NADPH + H+
reduced bacilliredoxin BrxA + NADP+
-
-
-
?
BrxA bacilliredoxin disulfide + NADPH + H+
reduced bacilliredoxin BrxA + NADP+
-
-
-
?
BrxB bacilliredoxin disulfide + NADPH + H+
reduced bacilliredoxin BrxB + NADP+
-
-
-
?
BrxB bacilliredoxin disulfide + NADPH + H+
reduced bacilliredoxin BrxB + NADP+
-
-
-
?
BrxC bacilliredoxin disulfide + NADPH + H+
reduced bacilliredoxin BrxC + NADP+
-
-
-
?
BrxC bacilliredoxin disulfide + NADPH + H+
reduced bacilliredoxin BrxC + NADP+
-
-
-
?
oxidized bacillithiol disulfide + NADH + H+
reduced bacillithiol disulfide + NAD+
-
-
-
r
oxidized bacillithiol disulfide + NADH + H+
reduced bacillithiol disulfide + NAD+
-
-
-
r
oxidized bacillithiol disulfide + NADH + H+
reduced bacillithiol disulfide + NAD+
Staphylococcus aureus PS 47
-
-
-
r
oxidized bacillithiol disulfide + NADPH + H+
reduced bacillithiol disulfide + NADP+
-
-
-
r
oxidized bacillithiol disulfide + NADPH + H+
reduced bacillithiol disulfide + NADP+
-
-
-
r
oxidized bacillithiol disulfide + NADPH + H+
reduced bacillithiol disulfide + NADP+
Staphylococcus aureus PS 47
-
-
-
r
protein-disulfide + NADPH + H+
protein-dithiol + NADP+
the enzyme is involved in a thioredoxin like system with thioredoxin reductase (PH1426). The redox potential of the redox protein is similar to that of thioredoxin from Escherichia coli and lower than that of glutathione
-
-
?
protein-disulfide + NADPH + H+
protein-dithiol + NADP+
Pyrococcus furiosus OT-3
the enzyme is involved in a thioredoxin like system with thioredoxin reductase (PH1426). The redox potential of the redox protein is similar to that of thioredoxin from Escherichia coli and lower than that of glutathione
-
-
?
thioredoxin + NADP+
thioredoxin disulfide + NADPH
-
radical reduction, prevention of cells from UV-generated free radical caused damage on the skin
-
-
?
thioredoxin + NADP+
thioredoxin disulfide + NADPH
-
defense against oxidative stress
-
-
?
thioredoxin + NADP+
thioredoxin disulfide + NADPH
-
metabolic function of thioredoxin reductase-thioredoxin system: supplies reducing equivalents for a wide variety of acceptors, e.g. : ribonucleotide reductase, nonspecific protein disulfide reductase, methionine sulfoxide reductase, D-proline reductase
-
-
?
thioredoxin + NADP+
thioredoxin disulfide + NADPH
-
radical reduction, prevention of cells from UV-generated free radical caused damage on the skin
-
-
?
thioredoxin + NADP+
thioredoxin disulfide + NADPH
-
major anti-oxidant in keratinocytes, melanocytes, melanoma cells
-
-
?
thioredoxin + NADP+
thioredoxin disulfide + NADPH
-
reduction of free radicals at the surface of the epidermis, enzyme may play a role in physiology of pancreatic beta-cells
-
-
?
thioredoxin + NADP+
thioredoxin disulfide + NADPH
-
detoxification of hydrogen peroxide, protection of the cell against oxidative damage
-
-
?
thioredoxin + NADP+
thioredoxin disulfide + NADPH + H+
the enzyme forms a redox system with protein-disulfide oxidoreductase PhRP (PH0178)
-
-
?
thioredoxin + NADP+
thioredoxin disulfide + NADPH + H+
the enzyme forms a redox system with protein-disulfide oxidoreductase PhRP (PH0178)
-
-
?
thioredoxin + NADP+
thioredoxin disulfide + NADPH + H+
-
-
-
r
thioredoxin + NADP+
thioredoxin disulfide + NADPH + H+
-
-
-
r
thioredoxin + NADP+
thioredoxin disulfide + NADPH + H+
Thermosynechococcus vestitus
-
-
-
-
?
thioredoxin 2 + NADP+
thioredoxin 2 disulfide + NADPH + H+
-
TrxR2 prefers its endogenous substrate thioredocin 2 over thioredoxin 1 (10fold), whereas isoform TrxR1 efficiently reduces both thioredoxin 1 and thioredoxin 2
-
-
?
thioredoxin 2 + NADP+
thioredoxin 2 disulfide + NADPH + H+
-
-
-
-
?
thioredoxin disulfide + NADH + H+
thioredoxin + NAD+
-
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
DmTrxR catalyzes the reversible transfer of reducing equivalents from NADPH to DmTrx-2. This process is consistent with the corresponding redox potentials and is essential for GSSG/GSH cycling in Drosophila melanogaster, which is deficient in glutathione reductase
-
-
r
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
the tandem system involving thioredoxin reductase and thioredoxin proves to be operative for reducing low molecular weight disulfides, including putative physiological substrates as cystine and oxidized trypanothione
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
the enzyme (TrxR) can use NADPH to reduce thioredoxin disulfide which passes the reducing equivalent to its downstream substrates involved in various biomedical events, such as ribonucleotide reductase for deoxyribonucleotide and DNA synthesis, or peroxiredoxins for counteracting oxidative stress
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
-
?
additional information
?
-
-
NADPH-dependent thioredoxin reductase and 2-Cys peroxiredoxin system is suggested to be important for scavenging H2O2 independent of light-driven generation of reducing equivalents
-
-
?
additional information
?
-
-
plants of the ntra ntrb knockout mutant are viable and fertile, although with a wrinkled seed phenotype, slower plant growth, and pollen with reduced fitness. Neither cytosolic nor mitochondrial NADPH-dependent thioredoxin reductases are essential in plants
-
-
?
additional information
?
-
Bdr and BrxB function cooperatively to debacillithiolate OhrR
-
-
-
additional information
?
-
-
Bdr and BrxB function cooperatively to debacillithiolate OhrR
-
-
-
additional information
?
-
Bdr and BrxB function cooperatively to debacillithiolate OhrR
-
-
-
additional information
?
-
-
thioredoxin reductase is essential for thiol/disulfide redox control and oxidative stress survival of the anaerobe Bacteroides fragilis
-
-
?
additional information
?
-
-
EhTRXR and EhTRX41 could be assayed as a functional redox pair that, together with peroxiredoxin, mediates the NADPH-dependent reduction of hydrogen peroxide and tert-butyl hydroperoxide. It is proposed that this detoxifying system could be operative in vivo
-
-
?
additional information
?
-
-
in addition, the enzyme exhibits NAD(P)H dependent oxidase activity, which generates hydrogen peroxide from molecular oxygen
-
-
?
additional information
?
-
-
thioredoxin reductase is essential for formate dehydrogenase H production and for labelling the formate dehydrogenase H polypeptide with 75Se-selenite
-
-
?
additional information
?
-
HEK-293 cells overexpressing TrxR2 are more resistant to impairment of complex III bypassing function of TrxR2
-
-
?
additional information
?
-
HEK-293 cells overexpressing TrxR2 are more resistant to impairment of complex III bypassing function of TrxR2
-
-
?
additional information
?
-
-
HEK-293 cells overexpressing TrxR2 are more resistant to impairment of complex III bypassing function of TrxR2
-
-
?
additional information
?
-
function of TRXR1 in the self-defense mechanism against self-generated oxidative stress
-
-
?
additional information
?
-
-
function of TRXR1 in the self-defense mechanism against self-generated oxidative stress
-
-
?
additional information
?
-
-
the combination of thioredioxin and thioredoxin reductase revives the activity of glutathione reductase from both the cortex and nucleus of aged clear lenses. In cataract lenses (grade II and grade IV) there is a statistically significant recovery of glutathione reductase activity in the cortex, but not in the nucleus
-
-
?
additional information
?
-
homozygous (-/-) knockout of Txnrd1 is embryonically lethal. No major effect of Txnrd1 hemizygosity and/or Se on male fertility and the viability of offspring
-
-
?
additional information
?
-
homozygous (-/-) knockout of Txnrd1 is embryonically lethal. No major effect of Txnrd1 hemizygosity and/or Se on male fertility and the viability of offspring
-
-
?
additional information
?
-
homozygous (-/-) knockout of Txnrd2 is embryonically lethal. No major effect of Txnrd2 hemizygosity and/or Se on male fertility and the viability of offspring
-
-
?
additional information
?
-
homozygous (-/-) knockout of Txnrd2 is embryonically lethal. No major effect of Txnrd2 hemizygosity and/or Se on male fertility and the viability of offspring
-
-
?
additional information
?
-
-
the enzyme can promote oxidative stress by redox cycling of paraquat: paraquat + O2 + NADPH + H+ --> paraquat radical + O2- radical + NADP+
-
-
?
additional information
?
-
-
ribonucleotide reductase, thioredoxin and thioredoxin reductase constitute a system necessary for the biosynthesis of deesoxyribonucleotides
-
-
?
additional information
?
-
mitochondrial respiratory chain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity
-
-
?
additional information
?
-
-
the yeast enzyme fails to reduce the human and Escherichia coli thioredoxin
-
-
?
additional information
?
-
Thermosynechococcus vestitus
-
NADPH thioredoxin reductase C functions as an electron donor to 2-Cys peroxiredoxin and transfers the reducing power from NADPH to the peroxiredoxin, which reduces peroxides in the cyanobacterium under oxidative stress
-
-
?
additional information
?
-
-
the enzyme cannot use thioredoxin from Spirulina as an electron acceptor
-
-
?
additional information
?
-
-
the enzyme cannot use thioredoxin from Spirulina as an electron acceptor
-
-
?
