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1.8.1.9: thioredoxin-disulfide reductase

This is an abbreviated version!
For detailed information about thioredoxin-disulfide reductase, go to the full flat file.

Word Map on EC 1.8.1.9

Reaction

thioredoxin
+
NADP+
=
thioredoxin disulfide
+
NADPH
+
H+

Synonyms

all0737, ApTR, At2g41680, AtNTRA, AtNTRB, bacillithiol disulfide reductase, bacillithiol-disulfide reductase, BBOV_I002190, Bdr, BSSB reductase, CeTR2, DmTR, DmTrxR, DmTrxR-1, EC 1.6.4.5, EhTRXR, ferredoxin:thioredoxin reductase, FTR, general stress protein 35, GSP35, HCOI_01258400, hemolysate thioredoxin reductase, hemolysate TR, hTrxR, HvNTR1, HvNTR2, L-TR, L-TrxR, More, MtNTRC, mTR3, multifunctional thioredoxin-glutathione reductase, NAD(P)H:paraquat oxidoreductase, NADP-dependent thioredoxin reductase, NADP-linked thioredoxin reductase, NADP-thioredoxin reductase, NADP-thioredoxin reductase C, NADPH thioredoxin reductase, NADPH thioredoxin reductase C, NADPH-dependent thioredoxin reductase, NADPH-dependent thioredoxin reductase 2, NADPH-dependent thioredoxin reductase C, NADPH-dependent thioredoxin reductase I, NADPH-dependent thioredoxin reductase-1, NADPH-dependent TRX reductase, NADPH-thioredoxin reductase, NADPH-thioredoxin reductase C, NADPH-Trx reductase, NADPH2:oxidized thioredoxin oxidoreductase, NAPDH-dependent BSSB reductase, NTR, Ntr1, NTR2, Ntr3, NTRA, NTRAB, NtrB, NTRC, PH0178, PH1426, PhRP, PhTrxR, protein-disulfide oxidoreductase, reductase, thioredoxin, SEP1, taTrxR, TGR, thioredoxin glutathione reductase, thioredoxin h reductase, thioredoxin reductase, thioredoxin reductase (NADPH), thioredoxin reductase 1, thioredoxin reductase 2, thioredoxin reductase-1, thioredoxin reductase1, TON_1603, TR, TR1, TR2, TR3, TRase, TrR, Trr1, Trr1p, TRR2, Trx1, Trx3, TrxB, TrxB1, TrxB2, TrxR, TrxR-1(cyto), TrxR-1(mito), TrxR1, TrxR2, TrxR3, TrxRB3, TRXRD, TrxRh1, TrxRh2, TrxT, Txnrd1, TXNRD1-v3, Txnrd2, TXNRD3, TxrR-1, YpdA

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.1 With NAD+ or NADP+ as acceptor
                1.8.1.9 thioredoxin-disulfide reductase

Source Tissue

Source Tissue on EC 1.8.1.9 - thioredoxin-disulfide reductase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
human kidney renal cell carcinoma
Manually annotated by BRENDA team
-
cortex
Manually annotated by BRENDA team
development and differentiation of the cells from transgenic mice lacking Txnrd2 expression is not significantly impaired
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
from dry and germinating seeds
Manually annotated by BRENDA team
-
genetic polymorphisms in the human selenoprotein P gene is associated with differences in thioredoxin reductase 1 concentrations
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
TXNRD1_v3 is induced by estradiol or testosterone treatments
Manually annotated by BRENDA team
Bach1 repression of ferritin and thioredoxin reductase1 is heme-sensitive in cells and in vitro and coordinates expression with heme oxygenase1, beta-globin, and NADP(H) quinone (oxido) reductase1
Manually annotated by BRENDA team
TXNRD1_v3 is predominantly expressed in the Leydig cells
Manually annotated by BRENDA team
quantification of the expression of alternative mRNA forms (alpha1/2, alpha6, alpha7/8, alpha10/11, alpha13, gamma2-4, and beta1) in six different human malignant mesothelioma cell lines of epithelioid (STAV-AB and M-14-K), sarcomatoid (STAV-FCS and ZL34), or mixed phenotype (M-28-K and M-9-K). The lowest level of TrxR1 is seen for the two sarcomatoid forms (STAV-FCS and ZL34), whereas the epithelioid phenotypes generally show very high levels of TrxR1. The major transcript form expressed in all cell lines is alpha1/2, followed by alpha7/8. The lowest level is observed for alpha6, which comprises less than 1% of the total a forms
Manually annotated by BRENDA team
TXNRD1_v3 is induced by estradiol or testosterone treatments
Manually annotated by BRENDA team
TGF-betA1-treatment up-regulated thioredoxin reductase 1
Manually annotated by BRENDA team
-
cerebellar granule neuron
Manually annotated by BRENDA team
H157, U1810 and H611. Selenium treatment results in increased expression of almost all TrxR1 mRNA variants with increasing concentrations of selenite
Manually annotated by BRENDA team
in some case of glucocorticoid-resistant alopecia areata patients, the expression of TrxR1 is decreased in outer root sheath
Manually annotated by BRENDA team
-
inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells
Manually annotated by BRENDA team
-
TrxR activity declines in during the first 21 days in milk. TrxR may be an important antioxidant defense mechanism in peripheral blood mononuclear cells that is compromised during the periparturient period
Manually annotated by BRENDA team
from 2-4-day-old seedlings, high accumulation
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
U1906E and U1906L. Selenium treatment results in increased expression of almost all TrxR1 mRNA variants with increasing concentrations of selenite
Manually annotated by BRENDA team
human cell glioblastoma
Manually annotated by BRENDA team
transcription of TXNRD1 involves alternative splicing, leading to a number of transcripts also encoding isoforms of TrxR1 that differ from each other at their N-terminal domains. The TXNRD1_v3 isoform contains an atypical N-terminal glutaredoxin domain. Expression of the transcript of this isoform is found predominantly in testis but is also detected in ovary, spleen, heart, liver, kidney, and pancreas
Manually annotated by BRENDA team
thioredoxin reductase 1 is upregulated in synovial cell from patients with rheumatoid arthritis. TRXR1 suppresses hydrogen peroxide and inhibits apoptosis of rheumatoid arthritis synovial cells
Manually annotated by BRENDA team
-
thioredoxin reductase activity in rheumatoid arthritis cells is significantly higher than in osteoarthritis cells
Manually annotated by BRENDA team
development and differentiation of the cells from transgenic mice lacking Txnrd2 expression is not significantly impaired
Manually annotated by BRENDA team
Hg(II) potently inhibits (at concentrations of 5-50 nM) TrxR1 activity in both cell-free and intracellular assays
Manually annotated by BRENDA team
TXNRD1_v3 is induced by estradiol or testosterone treatments
Manually annotated by BRENDA team
additional information