1.8.4.11: peptide-methionine (S)-S-oxide reductase

This is an abbreviated version!
For detailed information about peptide-methionine (S)-S-oxide reductase, go to the full flat file.

Reaction

Synonyms

EC 1.8.4.6, ecdysone-induced protein 28/29 kDa, FMsr, LIC_10545, LIC_12978, linmsra1, linmsra2, LMJF_07_1140, methionine S-oxide reductase (S-form oxidizing), methionine sulfoxide reductase, methionine sulfoxide reductase A, methionine sulfoxide reductases A, methionine sulfoxide-S-reductase, methionine sulphoxide reductase, methionine sulphoxide reductase A, methionine-S-sulfoxide reductase, MetSO-L12 reductase, More, mrsA, MSR, MSR10, MSR180, MsrA, MSRA-1, MsrA/B, MsrA/MsrB, MsrA1, MSRA2, MSRA4, msrAB, MsrABTk, MsrBA, Peptide Met(O) reductase, peptide methionine S-sulfoxide reductase, peptide methionine sulfoxide reductase, peptide methionine sulfoxide reductase A, peptide methionine sulfoxide reductase type A, peptide methionine sulphoxide reductase, peptide-methionine (S)-S-oxide reductase, peptide-methionine sulfoxide reductase, PilA, PilB, PilB protein, PMSR, PMSRA, protein-methionine-S-oxide-reductase, sulindac reductase, TbmsrA, TCDM_14270

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.4 With a disulfide as acceptor

                1.8.4.11 peptide-methionine (S)-S-oxide reductase

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Results	in table
24	Activating Compound
61413	AA Sequence
15	Application
90	Cloned(Commentary)
143	Cofactor
13	Crystallization (Commentary)
130	Disease/ Diagnostics
11	Expression
86	General Information
13	Inhibitors
43	kcat/KM [mM/s]
65	KM Value [mM]
96	Localization
16	Metals/Ions
33	Molecular Weight [Da]
202	Natural Substrates/ Products (Substrates)
8	Organic Solvent Stability
564	Organism
42	PDB ID
35	pH Optimum
4	pH Range
1	pI Value
2	Posttranslational Modification
113	Protein Variants
40	Purification (Commentary)
40	Reaction
314	Reference
161	Source Tissue
57	Specific Activity [micromol/min/mg]
2	Storage Stability
460	Substrates and Products (Substrate)
57	Subunits
472	Synonyms
1	Systematic Name
30	Temperature Optimum [°C]
3	Temperature Range [°C]
4	Temperature Stability [°C]
54	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.8.4.11 - peptide-methionine (S)-S-oxide reductase

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SYSTEMATIC NAME

IUBMB Comments

peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming]

The reaction occurs in the reverse direction to that shown above. The enzyme exhibits high specificity for the reduction of the S-form of L-methionine S-oxide, acting faster on the residue in a peptide than on the free amino acid [9]. On the free amino acid, it can also reduce D-methionine (S)-S-oxide but more slowly [9]. The enzyme plays a role in preventing oxidative-stress damage caused by reactive oxygen species by reducing the oxidized form of methionine back to methionine and thereby reactivating peptides that had been damaged. In some species, e.g. Neisseria meningitidis, both this enzyme and EC 1.8.4.12, peptide-methionine (R)-S-oxide reductase, are found within the same protein whereas, in other species, they are separate proteins [1,4]. The reaction proceeds via a sulfenic-acid intermediate [5,10].