1.8.4.12: peptide-methionine (R)-S-oxide reductase This is an abbreviated version! For detailed information about peptide-methionine (R)-S-oxide reductase, go to the full flat file .
Reaction
L-methionine (R)-sulfoxide +
thioredoxin =
L-methionine +
thioredoxin disulfide +
H2O
Synonyms 1-Cys methionine sulfoxide reductase B, 1-Cys MSRB, CBS-1, CBS1, cysteine-containing methionine-R-sulfoxide reductase, LOC100305558, LOC100798757, methionine sulfoxide reductase, methionine sulfoxide reductase B, methionine sulfoxide reductase B1, methionine sulfoxide reductase B2, methionine sulfoxide reductase B3, methionine sulfoxide reductase B8, methionine sulfoxide reductase MsrB3, methionine sulfoxide reductases B, methionine sulfoxide reductases B2, methionine sulphoxide reductase, methionine-R-sulfoxide reductase, methionine-R-sulfoxide reductase B, methionine-R-sulfoxide reductase B2, MetO reductase, More, MSR, MsrA, MsrA/B, MsrA/MsrB, msrAB, MsrABTk, MsrB, MSRB1, MsrB2, MsrB3, MsrB3A, MSRB4, MsrB5, MsrB7, MsrB8, MsrBA, Mxr2, NtMsrB2, OsMSRB5, PaMsrB1, peptide methionine sulfoxide reductase, peptide methionine sulfoxide reductase type B, PilB, PilB protein, PMSR, Sel-X, selenocysteine-containing methionine-R-sulfoxide reductase, selenoprotein R, SelR, sulindac reductase, TbmsrB, TCDM_06423, YeaA
ECTree
Localization
Localization on EC 1.8.4.12 - peptide-methionine (R)-S-oxide reductase
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secretion of MsrA, EC 1.8.4.11, and MsrB fused together
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protein storage vacuole
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plastidic isozyme pPMSR
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plastidic isozymes MsrB1 and MsrB2, analysis of subcellular localization
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sequence lacks any signal-peptide motif necessary for the protein transport across membranes
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sequence lacks any signal-peptide motif necessary for the protein transport across membranes
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dual localization, both in cytoplasm and periplasm
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Leptospira interrogans Fiocruz L1-130
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dual localization, both in cytoplasm and periplasm
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Sel-X, a MsrB enzyme form variant, sulindac reducing activity in calf
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Sel-X, a MsrB enzyme form variant
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isozyme MsrB1
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isozyme MsrB1 or selenoprotein R
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Sel-X, a MsrB enzyme variant
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isozyme MsrB1
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Sel-X, a MsrB enzyme form variant
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MsrB3 plays an important role in cold tolerance by eliminating methionine sulfoxide and reactive oxygen species that accumulate at the endoplasmic reticulum during cold acclimation
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sequence contains a a putative transmembrane domain and an ER-specific retention signal
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sequence contains a a putative transmembrane domain and an ER-specific retention signal
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isozyme MsrB3
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MsrB3A contains an endoplasmic reticulum signal peptide at the N-terminus and an endoplasmic reticulum retention signal at the C-terminus, and is targeted to the endoplasmic reticulum
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two splice variants of the enzyme (Msr B3) that differ in their N-terminal signal sequence, which directs the protein to either the endoplasmic reticulum (ER) or mitochondria
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isozyme MsrB3
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specific isozyme MsrB3
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MsrB3 has consecutive endoplasmic reticulum and mitochondrial targeting signals at the N-terminus. This protein is targeted to the endoplasmic reticulum, and the function of the mitochondrial signal appears to be masked by the endoplasmic reticulum signal peptide
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enzyme form Mem-R,S-Msr
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membrane-associated enzyme MsrB
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outer cell membrane
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calf, sulindac reducing activity
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Sel-X, a MsrB enzyme form variant, sulindac reducing activity in calf
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sequence contains a mitochondrial signal sequence
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sequence contains a mitochondrial signal sequence
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Sel-X, a MsrB enzyme form variant
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isozyme MsrB2 or CBS-1, and isozyme MsrB3
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isozymes MsrB2 and MsrB3
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MsrB3B contains a different signal peptide at the N-terminus and is targeted to mitochondria
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two splice variants of the enzyme (Msr B3) that differ in their N-terminal signal sequence, which directs the protein to either the endoplasmic reticulum (ER) or mitochondria
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Sel-X, a MsrB enzyme variant
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isozymes MsrB2 and MsrB3
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matrix
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Sel-X, a MsrB enzyme form variant
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sequence forms a monopartite nuclear localization signal
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sequence forms a monopartite nuclear localization signal
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isozyme MsrB1
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isozyme MsrB1 or selenoprotein R
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isozyme MsrB1
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dual localization, both in cytoplasm and periplasm
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Leptospira interrogans Fiocruz L1-130
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dual localization, both in cytoplasm and periplasm
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additional information
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subcellular sulindac reducing activity distribution in calf liver
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additional information
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no activity in the cytoplasm
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additional information
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subcellular targeting is determined by alternative splicing
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additional information
subcellular localization analysis, no localization of MsrB3 in the mitochondria
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additional information
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subcellular localization analysis, no localization of MsrB3 in the mitochondria
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additional information
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subcellular targeting is determined by alternative splicing
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