1.8.4.12: peptide-methionine (R)-S-oxide reductase
This is an abbreviated version!
For detailed information about peptide-methionine (R)-S-oxide reductase, go to the full flat file.
Word Map on EC 1.8.4.12
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1.8.4.12
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thioredoxins
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selenoproteins
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selenium
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msrbs
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neisseria
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metso
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trx
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sulfenic
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methionine-s-sulfoxide
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meningitidis
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thioredoxin-dependent
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selenoenzyme
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lincosamides
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synthesis
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biotechnology
- 1.8.4.12
- thioredoxins
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selenoproteins
- selenium
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msrbs
- neisseria
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metso
- trx
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sulfenic
- methionine-s-sulfoxide
- meningitidis
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thioredoxin-dependent
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selenoenzyme
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lincosamides
- synthesis
- biotechnology
Reaction
Synonyms
1-Cys methionine sulfoxide reductase B, 1-Cys MSRB, CBS-1, CBS1, cysteine-containing methionine-R-sulfoxide reductase, LOC100305558, LOC100798757, methionine sulfoxide reductase, methionine sulfoxide reductase B, methionine sulfoxide reductase B1, methionine sulfoxide reductase B2, methionine sulfoxide reductase B3, methionine sulfoxide reductase B8, methionine sulfoxide reductase MsrB3, methionine sulfoxide reductases B, methionine sulfoxide reductases B2, methionine sulphoxide reductase, methionine-R-sulfoxide reductase, methionine-R-sulfoxide reductase B, methionine-R-sulfoxide reductase B2, MetO reductase, More, MSR, MsrA, MsrA/B, MsrA/MsrB, msrAB, MsrABTk, MsrB, MSRB1, MsrB2, MsrB3, MsrB3A, MSRB4, MsrB5, MsrB7, MsrB8, MsrBA, Mxr2, NtMsrB2, OsMSRB5, PaMsrB1, peptide methionine sulfoxide reductase, peptide methionine sulfoxide reductase type B, PilB, PilB protein, PMSR, Sel-X, selenocysteine-containing methionine-R-sulfoxide reductase, selenoprotein R, SelR, sulindac reductase, TbmsrB, TCDM_06423, YeaA
ECTree
1.8.4.12 peptide-methionine (R)-S-oxide reductaseAdvanced search results
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results (Turnover Number
Turnover Number on EC 1.8.4.12 - peptide-methionine (R)-S-oxide reductase
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TURNOVER NUMBER [1/s] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.035
CDSP32
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pH 8.0, 37°C, cosubstrate: dabsyl-L-methionine (R)-sulfoxide, MSRB1 activity
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0.09
dithiothreitol
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recombinant enzyme, in 50 mM Tris-HCl, pH 8.0, at 37°C
0.0145
glutaredoxin
30°C, pH 7.0, cosubstrate: N-acetyl-L-methionine-(R)-S-oxide
2.8
L-methionine (R,S)-sulfoxide
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MsrB activity of PILB, pH 8.0, 25°C
0.0048
trypanothione disulfide
pH 7.5, 30°C, cosubstrate: N-acetyl-L-methionine-(R)-S-oxide, mutant enzyme C72S/C74S
0.004
dabsyl-L-methionine (R)-S-oxide
isolated MrsB domain, pH 7.5, 37°C
0.025
dabsyl-L-methionine (R)-S-oxide
mutant Y163A//E165A, pH 7.5, 37°C
0.002
dabsyl-L-methionine (R)-sulfoxide
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isoform MSRB1 wild type enzyme, in the presence of 20 mMTris(2-carboxyethyl) phosphine hydrochloride
0.005
dabsyl-L-methionine (R)-sulfoxide
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isoform MSRB1 mutant T132C, in the presence of 20 mM dithioerythritol
0.012
dabsyl-L-methionine (R)-sulfoxide
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isoform MSRB1 mutant T132A, in the presence of 20 mM dithioerythritol
0.014
dabsyl-L-methionine (R)-sulfoxide
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isoform MSRB2 wild type enzyme, in the presence of 20 mMTris(2-carboxyethyl) phosphine hydrochloride
0.028
dabsyl-L-methionine (R)-sulfoxide
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isoform MSRB2 wild type enzyme, in the presence of 20 mM dithioerythritol
0.045
dabsyl-L-methionine (R)-sulfoxide
pH 7.5, 37°C, mutant enzyme E339A
0.047
dabsyl-L-methionine (R)-sulfoxide
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isoform MSRB1 mutant C116S, in the presence of 20 mM dithioerythritol
0.05
dabsyl-L-methionine (R)-sulfoxide
pH 7.5, 37°C, mutant enzyme E193A/D197A
0.064
dabsyl-L-methionine (R)-sulfoxide
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isoform MSRB2 mutant C134T, in the presence of 20 mM dithioerythritol
0.073
dabsyl-L-methionine (R)-sulfoxide
pH 7.5, 37°C, mutant enzyme D197A
0.075
dabsyl-L-methionine (R)-sulfoxide
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isoform MSRB1 wild type enzyme, in the presence of 20 mM dithioerythritol
0.078
dabsyl-L-methionine (R)-sulfoxide
pH 7.5, 37°C, mutant enzyme E193A
0.087
dabsyl-L-methionine (R)-sulfoxide
pH 7.5, 37°C, mutant enzyme Y343F
0.157
dabsyl-L-methionine (R)-sulfoxide
pH 7.5, 37°C, wild-type enzyme
0.17
glutaredoxin S12
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pH 8.0, 37°C, cosubstrate: dabsyl-L-methionine (R)-sulfoxide, MSRB1 activity
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0.01
L-methionine (R)-sulfoxide
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in vitro, substrate free L-methionine (R)-sulfoxide
0.13
L-methionine (R)-sulfoxide
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isoform MSRB4, pH and temperature not specified in the publication
2.86
L-methionine (R)-sulfoxide
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isoform MSRB2, pH and temperature not specified in the publication
0.002
L-methionine-(R)-S-oxide
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recombinant wild-type cysteine-containing isozyme MsrB1 expressed in NIH 3T3 cells
0.002
L-methionine-(R)-S-oxide
pH 7.5, 30°C, cosubstrate: tryparedoxin I, wild-type enzyme
0.0076
L-methionine-(R)-S-oxide
30°C, pH 7.0, cosubstrate: glutaredoxin
0.02
L-methionine-(R)-S-oxide
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recombinant isozyme MsrB2, with dithioerythritol
0.07
L-methionine-(R)-S-oxide
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recombinant isozyme MsrB1, with dithioerythritol
0.22
L-methionine-(R)-S-oxide
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recombinant wild-type selenocysteine-containing isozyme MsrB1 expressed in NIH 3T3 cells
0.46
L-methionine-(R)-S-oxide
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recombinant wild-type isozyme MsrB2 expressed in Escherichia coli
0.83
L-methionine-(R)-S-oxide
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recombinant wild-type isozyme MsrB3 expressed in Escherichia coli
0.24
N-acetyl-L-methionine (R)-sulfoxide
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isoform MSRB4, pH and temperature not specified in the publication
2.04
N-acetyl-L-methionine (R)-sulfoxide
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isoform MSRB2, pH and temperature not specified in the publication
0.00052
N-acetyl-L-methionine-(R)-S-oxide
pH 7.5, 30°C, cosubstrate: tryparedoxin I, mutant enzyme C72S
0.0016
N-acetyl-L-methionine-(R)-S-oxide
pH 7.5, 30°C, cosubstrate: tryparedoxin I, mutant enzyme C74S
0.0023
N-acetyl-L-methionine-(R)-S-oxide
pH 7.5, 30°C, cosubstrate: trypanothione, mutant enzyme C72S/C74S
0.0048
N-acetyl-L-methionine-(R)-S-oxide
pH 7.5, 30°C, cosubstrate: tryparedoxin I, wild-type enzyme
0.014
N-acetyl-L-methionine-(R)-S-oxide
30°C, pH 7.0, cosubstrate: glutaredoxin
0.0043
thioredoxin
30°C, pH 7.0, cosubstrate: N-acetyl-L-methionine-(R)-S-oxide
0.0056
thioredoxin
pH 7.5, 30°C, cosubstrate: N-acetyl-L-methionine-(R)-S-oxide, wild-type enzyme
0.00067
tryparedoxin I
pH 7.5, 30°C, cosubstrate: N-acetyl-L-methionine-(R)-S-oxide, mutant enzyme C72S
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0.0025
tryparedoxin I
pH 7.5, 30°C, cosubstrate: N-acetyl-L-methionine-(R)-S-oxide, mutant enzyme C74S
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0.00583
tryparedoxin I
pH 7.5, 30°C, cosubstrate: N-acetyl-L-methionine-(R)-S-oxide, wild-type enzyme
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additional information
additional information
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reductase step kinetic parameters of the wild-type and mutated MsrB
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