1.8.4.14: L-methionine (R)-S-oxide reductase
This is an abbreviated version!
For detailed information about L-methionine (R)-S-oxide reductase, go to the full flat file.
Word Map on EC 1.8.4.14
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1.8.4.14
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methionine-r-sulfoxide
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reductases
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cys
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msrbs
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lifespan
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unicellular
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diastereomers
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sulfenic
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thiol-dependent
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aureus
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glutaredoxin
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protein-based
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trx
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selenocysteine
- 1.8.4.14
- methionine-r-sulfoxide
- reductases
- cys
-
msrbs
-
lifespan
-
unicellular
-
diastereomers
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sulfenic
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thiol-dependent
- aureus
- glutaredoxin
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protein-based
- trx
- selenocysteine
Reaction
Synonyms
EC 1.8.4.5, fRMsr, methionine sulfoxide reductase, methionine-R-sulfoxide reductase, NMV_2074, TafRMsr
ECTree
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Substrates Products
Substrates Products on EC 1.8.4.14 - L-methionine (R)-S-oxide reductase
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REACTION DIAGRAM
L-methionine-(R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
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L-methionine + thioredoxin disulfide + H2O
fRMsr exhibits the highest Met-(R)-O reductase activity when all components of the NADPHTrxR-Trx system are present in the reaction. The enzyme is not able to reduce L-methionine (S)-S-oxide, Met sulfone, dimethyl sulfoxide, or MetO when present in the synthetic peptide NH2-Pro-Thr-Ser-Met-(RS)-O-Glu-His-Val-NH2. Escherichia coli fRMsr is the first GAF domain family member to show enzymatic activity
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L-methionine (R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
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L-methionine (R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
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L-methionine (R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
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the enzyme only reduces the free form of methionine-R-sulfoxide
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L-methionine (R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
the enzyme exhibits strict substrate specificity toward free L-methionine (R)-S-oxide and is unable to reduce dabsylated (peptidyl) L-methionine (R)-S-oxide, free L-methionine S-oxide, or dimethylsulfoxide
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L-methionine + thioredoxin disulfide + H2O
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L-methionine (R)-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
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L-methionine (R)-S-oxide + thioredoxin
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enzyme specific for free L-methionine-(R)-sulfoxide and not met-R-(o) in peptide linkage
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L-methionine + thioredoxin disulfide + H2O
L-methionine (R)-S-oxide + thioredoxin
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enzyme specific for free L-methionine-(R)-sulfoxide and not met-R-(o) in peptide linkage
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no activity with peptide-L-methionine-(R)-S-oxide
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additional information
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in the absence of thioredoxin, 1 mol of Met/subunit is formed
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additional information
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in the absence of thioredoxin, 1 mol of Met/subunit is formed
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