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1.8.4.2: protein-disulfide reductase (glutathione)

This is an abbreviated version!
For detailed information about protein-disulfide reductase (glutathione), go to the full flat file.

Word Map on EC 1.8.4.2

Reaction

2 glutathione +

protein-disulfide
=
glutathione-disulfide
+
protein-dithiol

Synonyms

BbdC, BdbD, C1orf31, CatA protein, ccdA associated thiol-disulfide oxidoreductase, COA6, DcbA, desulfothioredoxin, DIP1880, disulfide bond-forming thiol-disulfide oxidoreductase, disulphide interchange enzyme, DsbA, DsbA1, DsbA2, Dtrx, ERp57, GIT, glutathione-insulin transhydrogenase, glutathione-protein disulfide oxidoreductase, GRX1, GRX2, GRX3, GRX5, GRX6, GrxS12, GSH-dependent protein disulfide oxidoreductase, GSH-insulin transhydrogenase, HP_0231, insulin reductase, mcrophage migration inhibitory factor-2, MdbA, MdbACm, membrane-bound thiol-disulfide oxidoreductase, Mif-2, More, protein disulfide reductase (glutathione), protein disulfide transhydrogenase, protein-disulfide interchange enzyme, protein-disulfide isomerase/oxidoreductase, RCAP_rcc01743, reductase, protein disulfide (glutathione), ResA, SdbA, SGO_2006, SpyM18_2037, StoA, Streptococcus disulfide bond protein A, TDOR, thiol disulfide oxidoreductase, thiol-disulfide oxidoreductase, thiol-protein disulphide oxidoreductase, thiol:disulfide oxidoreductase, thiol:protein-disulfide oxidoreductase, WhiB1, WhiB1/Rv3219, YkuV, YMR244C-A

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.4 With a disulfide as acceptor
                1.8.4.2 protein-disulfide reductase (glutathione)

Inhibitors

Inhibitors on EC 1.8.4.2 - protein-disulfide reductase (glutathione)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,3-Bis(2-chloroethyl)-1-nitrosourea
Aprotinin
arsenite
bacitracin
cysteine
-
at high concentration
deoxycholate
glucagon
-
-
GSSG
-
product inhibition
guanidinium hydrochloride
-
destroys zinc finger thiols of DnaJ protein
H2O2
-
-
Insulin analogs
-
competitive inhibition of insulin degradation, overview
-
iodoacetamide
iodoacetate
lysolecithin
lysophosphatidylcholine
N-acetyl-L-tyrosine ethyl ester
-
-
N-ethylmaleimide
-
treatment with thiol prior to incubation with GSH and substrate: no inhibition, preincubation with GSH and thiol reagent: inhibition
Oxytoxin
-
-
Phenylarsine oxide
phosphatidic acid
ribonuclease
-
-
-
S-Sulfonated A-chain or B-chain of insulin
-
product inhibition
-
Scrambled forms of ribonuclease and lysozyme
-
inhibition of insulin degradation
-
selenium oxide
-
-
Triton X-100
-
inhibitory for the solubilized enzyme
Vasopressin
-
-
additional information
-