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1.8.4.2: protein-disulfide reductase (glutathione)

This is an abbreviated version!
For detailed information about protein-disulfide reductase (glutathione), go to the full flat file.

Word Map on EC 1.8.4.2

Reaction

2 glutathione +

protein-disulfide
=
glutathione-disulfide
+
protein-dithiol

Synonyms

BbdC, BdbD, C1orf31, CatA protein, ccdA associated thiol-disulfide oxidoreductase, COA6, DcbA, desulfothioredoxin, DIP1880, disulfide bond-forming thiol-disulfide oxidoreductase, disulphide interchange enzyme, DsbA, DsbA1, DsbA2, Dtrx, ERp57, GIT, glutathione-insulin transhydrogenase, glutathione-protein disulfide oxidoreductase, GRX1, GRX2, GRX3, GRX5, GRX6, GrxS12, GSH-dependent protein disulfide oxidoreductase, GSH-insulin transhydrogenase, HP_0231, insulin reductase, mcrophage migration inhibitory factor-2, MdbA, MdbACm, membrane-bound thiol-disulfide oxidoreductase, Mif-2, More, protein disulfide reductase (glutathione), protein disulfide transhydrogenase, protein-disulfide interchange enzyme, protein-disulfide isomerase/oxidoreductase, RCAP_rcc01743, reductase, protein disulfide (glutathione), ResA, SdbA, SGO_2006, SpyM18_2037, StoA, Streptococcus disulfide bond protein A, TDOR, thiol disulfide oxidoreductase, thiol-disulfide oxidoreductase, thiol-protein disulphide oxidoreductase, thiol:disulfide oxidoreductase, thiol:protein-disulfide oxidoreductase, WhiB1, WhiB1/Rv3219, YkuV, YMR244C-A

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.4 With a disulfide as acceptor
                1.8.4.2 protein-disulfide reductase (glutathione)

KM Value

KM Value on EC 1.8.4.2 - protein-disulfide reductase (glutathione)

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.2
2-mercaptoethanol
-
-
0.2 - 2.65
2-mercaptoethanol glutathione disulfide
-
0.27
cysteine
-
-
0.14
dihydrolipoamide
-
-
0.2
dihydrolipoate
-
-
2.65 - 5
glutathione
0.028 - 0.03
glutathionylated BSA
-
0.00087 - 0.00454
glutathionylated glyceraldehyde-3-phosphate dehydrogenase
-
0.0082 - 0.0265
glutathionylated isocitrate lyase
-
0.31 - 1.7
GSH
0.003 - 0.031
Insulin
-
0.13
reduced dithiothreitol
-
-
-
additional information
additional information
-