1.8.98.2: sulfiredoxin

This is an abbreviated version!
For detailed information about sulfiredoxin, go to the full flat file.

Word Map on EC 1.8.98.2

1.8.98.2

peroxiredoxins

hyperoxidation

thioredoxins

overoxidized

sulfenic

peroxidatic

txnrd1

sulfinylated

deglutathionylation

prxiii

prdxs

cys-so2h

medicine

drug development

Reaction

+ 2 R-SH =

Synonyms

AtSrx, cysteine-sulfinic acid reductase, neoplastic progression 3, peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase, protein cysteine sulfinic acid reductase, Srx, Srx1, Srxn1, sulfiredoxin, sulfiredoxin 1, sulfiredoxin-1, sulphiredoxin

ECTree

1 Oxidoreductases

1.8 Acting on a sulfur group of donors

1.8.98 With other, known, physiological acceptors

1.8.98.2 sulfiredoxin

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Results	in table
1	Activating Compound
1793	AA Sequence
5	Application
1	CAS Registry Number
19	Cloned(Commentary)
17	Cofactor
4	Crystallization (Commentary)
228	Disease/ Diagnostics
8	Expression
18	General Information
2	IC50 Value
9	Inhibitors
8	KM Value [mM]
20	Localization
11	Metals/Ions
6	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
50	Organism
26	PDB ID
3	pH Optimum
3	pI Value
36	Protein Variants
9	Purification (Commentary)
1	Reaction
17	Reaction Type
44	Reference
40	Source Tissue
73	Substrates and Products (Substrate)
3	Subunits
54	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
5	Turnover Number [1/s]

Expression

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Expression on EC 1.8.98.2 - sulfiredoxin

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adrenocortical tumor cell lines show increased enzyme expression. Adrenocorticotropic hormone also induces upregulation of the enzyme with its levels peaking at 3-6 h after injection of adrenocorticotropic hormone

Mus musculus

743228

disruption of Nrf2 signaling down-regulates the expression of Srx1

2 entries

high glucose induces enzyme expression

Rattus norvegicus

742457

Nrf2, nuclear factor erythroid-2-related factor, up-regulates Srx1 expression during oxidative stress caused by cigarette smoke exposure in the lungs

2 entries

oxidative stress and growth factors can markedly upregulate Srx transcript and protein levels

Homo sapiens

700520

under the oxidation stress elicited by hydrogen peroxide, the transcription level of AtSrx is significantly increased

Arabidopsis thaliana

Q8GY89

764076