1.97.1.4: [formate-C-acetyltransferase]-activating enzyme

This is an abbreviated version!
For detailed information about [formate-C-acetyltransferase]-activating enzyme, go to the full flat file.

Reaction

Synonyms

Activase, pyruvate formate-lyase, Formate acetyltransferase activase, Formate-lyase-activating enzyme, PFL, PFL activase, PFL activating enzyme, PFL-activating enzyme, PFL-AE, PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving), PflA, pyruvate formate lyase activating enzyme, Pyruvate formate-lyase activase, Pyruvate formate-lyase activating enzyme, pyruvate formate-lyase-activating enzyme

ECTree

     1 Oxidoreductases

         1.97 Other oxidoreductases

             1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

                1.97.1.4 [formate-C-acetyltransferase]-activating enzyme

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Results	in table
3	Activating Compound
11817	AA Sequence
1	Application
1	CAS Registry Number
9	Cloned(Commentary)
8	Cofactor
1	Crystallization (Commentary)
1	Expression
10	General Information
4	Inhibitors
3	KM Value [mM]
3	Localization
14	Metals/Ions
8	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
27	Organism
2	PDB ID
4	pH Optimum
1	pI Value
10	Protein Variants
5	Purification (Commentary)
4	Reaction
2	Reaction Type
26	Reference
1	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
29	Substrates and Products (Substrate)
5	Subunits
27	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 1.97.1.4 - [formate-C-acetyltransferase]-activating enzyme

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

S-Adenosyl-L-methionine + dihydroflavodoxin + formate acetyltransferase-glycine

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Escherichia coli

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14938

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-

?

S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine

5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical

Escherichia coli

P0A9N4

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744943, 745316

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-

?

additional information

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3 entries

additional information

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Escherichia coli

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pyruvate formate-lyase-activating enzyme (PFL-AE) activates pyruvate formate-lyase by generating a catalytically essential radical on Gly-734 of pyruvate formate-lyase. PFL-AE shifts the closed/open formation of pyruvate formate-lyase to the open conformation, in which Gly-734 is more solvent-exposed and accessible to the PFL-AE active site

715533

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-

?

additional information

?

-

Escherichia coli

P0A9N4

pyruvate formate-lyase-activating enzyme (PFL-AE) activates pyruvate formate-lyase by generating a catalytically essential radical on Gly-734 of pyruvate formate-lyase. PFL-AE shifts the closed/open formation of pyruvate formate-lyase to the open conformation, in which Gly-734 is more solvent-exposed and accessible to the PFL-AE active site

715533

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-

?

additional information

?

-

Escherichia coli

P0A9N4

in vivo concentrations of the entire PFL system is calculated to estimate the amount of bound protein in the cell. PFL, PFL-AE, and S-adenosyl-L-methionine are essentially fully bound in vivo, whereas electron donor proteins are partially bound

745316

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-

?