2.1.1.1: nicotinamide N-methyltransferase
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For detailed information about nicotinamide N-methyltransferase, go to the full flat file.
Reaction
Synonyms
ANMT-1, B0303.2, methyltransferase, nicotinamide, nicotinamide N-methyl transferase, nicotinamide N-methyltransferase, NNMT
ECTree
2.1.1.1 nicotinamide N-methyltransferaseAdvanced search results
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results (Engineering
Engineering on EC 2.1.1.1 - nicotinamide N-methyltransferase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
K100A/E101A/E103A
His-tagged version, crystallization facilitated by reducing the entropy of three surface exposed residues
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enzyme upregulation correlates with tumour differentiation in oral squamous cell carcinoma cells
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identification of 11 single nucleotide polymorphisms in the 5'-UTR and 3'-UTR, as well as in exon 1 and intron 2, overview
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siRNA knockdown of NNMT in SLT4 cells causes decreased cell proliferation in bladder cancer, the enzyme expression is associated with cell migration
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downregulation of enzyme NNMT expression in HT-29 cells. Balb/c mice are injected with NNMT-transfected SW-480 cells, the enzyme significantly accelerates cell proliferation and enhances tumorigenicity in mice
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enzyme expression in SH-SY5Y neuroblastoma and N27 mesencephalic neurones induces changes in cell morphology via ephrin-B2 and Akt signalling
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forced NNMT overexpression strongly induces the invasive capacity in human embryonic kidney 293 cells
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gain-of-function non-coding micro-RNA-1291 (miR-1291) transfected to PANC-1 cells lead to a significantly altered metabolome for the human pancreatic carcinoma cells, phenotype with a lower migration and invasion capacity as well as suppressed tumorigenesis in a xenograft tumor mouse model. A number of metabolites, including N-methylnicotinamide, involved in nicotinamide metabolism, and l-carnitine, isobutyryl-carnitine and isovaleryl-carnitine, involved in fatty acid metabolism, are elevated in miR-1291-expressing PANC-1. N-methylnicotinamide is elevated to the greatest extent associated with a sharp increase in nicotinamide N-methyltransferase (NNMT) mRNA level in miR-1291-expressing PANC-1 cells. The expression of NNMT mRNA is inversely correlated with pancreatic tumor size in the xenograft mouse model
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transfection of pancreatic cancer cell line PANC-1 with NNMT expression plasmid or small interfering RNA of NNMT to overexpress or knockdown intracellular NNMT expression, respectively. Enzyme silencing markedly reduces cell proliferation, whereas enzyme overexpression promotes cell growth moderately. Enzyme knockdown by specific siRNA
