2.1.1.1: nicotinamide N-methyltransferase
This is an abbreviated version!
For detailed information about nicotinamide N-methyltransferase, go to the full flat file.
Reaction
Synonyms
ANMT-1, B0303.2, methyltransferase, nicotinamide, nicotinamide N-methyl transferase, nicotinamide N-methyltransferase, NNMT
ECTree
2.1.1.1 nicotinamide N-methyltransferaseAdvanced search results
results (
results (Reference
top
Reference on EC 2.1.1.1 - nicotinamide N-methyltransferase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cantoni, G.L.
Methylation of nicotinamide with a soluble enzyme system from rat liver
J. Biol. Chem.
189
203-217
1951
Rattus norvegicus
Alston, T.A.; Abeles, R.H.
Substrate specificity of nicotinamide methyltransferase isolated from porcine liver
Arch. Biochem. Biophys.
260
601-608
1988
Sus scrofa
Rini, J.; Szumlanski, C.; Guerciolini, R.; Weinshilboum, R.M.
Human liver nicotinamide N-methyltransferase: ion-pairing radiochemical assay, biochemical properties and individual variation
Clin. Chim. Acta
186
359-374
1990
Homo sapiens
Smith, M.L.; Burnett, D.; Bennett, P.; Waring, R.H.; Brown, H.M.; Williams, A.C.; Ramsden, D.B.
A direct correlation between nicotinamide N-methyltransferase activity and protein levels in human liver cytosol
Biochim. Biophys. Acta
1442
238-244
1998
Homo sapiens
Aksoy, S.; Szumlanski, C.L.; Weinshilboum, R.M.
Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization
J. Biol. Chem.
269
14835-14840
1994
Homo sapiens
Yan, L.; Otterness, D.M.; Kozak, C.A.; Weinshilboum, R.M.
Mouse nicotinamide N-methyltransferase gene: molecular cloning, structural characterization, and chromosomal localization
DNA Cell Biol.
17
659-667
1998
Mus musculus
Fujimura, S.; Okamura, A.; Ohmura, Y.; Moriyama, Y.; Ohwada, H.; Horitsu, K.; Ohkubo, M.
Nicotinamide methyltransferase activity and cell-death in the liver of the mouse bearing Ehrlich ascites tumor
Adv. Exp. Med. Biol.
398
507-511
1996
Mus musculus, Rattus norvegicus
Scheller, T.; Orgacka, H.; Szumlanski, C.L.; Weinshilboum, R.M.
Mouse liver nicotinamide N-methyltransferase pharmacogenetics: biochemical properties and variation in activity among inbred strains
Pharmacogenetics
6
43-53
1996
Mus musculus, Mus musculus C57/BL6J
Aoyama, K.; Matsubara, K.; Kondo, M.; Murakawa, Y.; Suno, M.; Yamashita, K.; Yamaguchi, S.; Kobayashi, S.
Nicotinamide-N-methyltransferase is higher in the lumbar cerebrospinal fluid of patients with Parkinson's disease
Neurosci. Lett.
298
78-80
2001
Homo sapiens
Kassem, H.S.; Sangar, V.; Cowan, R.; Clarke, N.; Margison, G.P.
A potential role of heat shock proteins and nicotinamide N-methyl transferase in predicting response to radiation in bladder cancer
Int. J. Cancer
101
454-460
2002
Homo sapiens
Okamura, A.; Ohmura, Y.; Islam, M.M.; Tagawa, M.; Horitsu, K.; Moriyama, Y.; Fujimura, S.
Increased hepatic nicotinamide N-methyltransferase activity as a marker of cancer cachexia in mice bearing colon 26 adenocarcinoma
Jpn. J. Cancer Res.
89
649-656
1998
Mus musculus
Parsons, R.B.; Smith, M.L.; Williams, A.C.; Waring, R.H.; Ramsden, D.B.
Expression of nicotinamide N-methyltransferase (E.C. 2.1.1.1) in the Parkinsonian brain
J. Neuropathol. Exp. Neurol.
61
111-124
2002
Homo sapiens
Xu, J.; Moatamed, F.; Caldwell, J.S.; Walker, J.R.; Kraiem, Z.; Taki, K.; Brent, G.A.; Hershman, J.M.
Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells
J. Clin. Endocrinol. Metab.
88
4990-4996
2003
Homo sapiens
Parsons, R.B.; Smith, S.W.; Waring, R.H.; Williams, A.C.; Ramsden, D.B.
High expression of nicotinamide N-methyltransferase in patients with idiopathic Parkinson's disease
Neurosci. Lett.
342
13-16
2003
Homo sapiens
van Driel, L.M.; Smedts, H.P.; Helbing, W.A.; Isaacs, A.; Lindemans, J.; Uitterlinden, A.G.; van Duijn, C.M.; de Vries, J.H.; Steegers, E.A.; Steegers-Theunissen, R.P.
Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide
Eur. Heart J.
29
1424-1431
2008
Homo sapiens (P40261), Homo sapiens
Tomida, M.; Ohtake, H.; Yokota, T.; Kobayashi, Y.; Kurosumi, M.
Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells
J. Cancer Res. Clin. Oncol.
134
551-559
2008
Homo sapiens (P40261), Homo sapiens
Sartini, D.; Santarelli, A.; Rossi, V.; Goteri, G.; Rubini, C.; Ciavarella, D.; Lo Muzio, L.; Emanuelli, M.
Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma
Mol. Med.
13
415-421
2007
Homo sapiens (P40261)
Zhang, L.; Miyaki, K.; Araki, J.; Nakayama, T.; Muramatsu, M.
The relation between nicotinamide N-methyltransferase gene polymorphism and plasma homocysteine concentration in healthy Japanese men
Thromb. Res.
121
55-58
2007
Homo sapiens (P40261), Homo sapiens
Riederer, M.; Erwa, W.; Zimmermann, R.; Frank, S.; Zechner, R.
Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine
Atherosclerosis
204
412-417
2009
Homo sapiens, Mus musculus
Lu, W.; Zhu, H.; Wen, S.; Yang, W.; Shaw, G.M.; Lammer, E.J.; Finnell, R.H.
Nicotinamide N-methyl transferase (NNMT) gene polymorphisms and risk for spina bifida
Birth Defects Res. Part A Clin. Mol. Teratol.
82
670-675
2008
Homo sapiens
Emanuelli, M.; Santarelli, A.; Sartini, D.; Ciavarella, D.; Rossi, V.; Pozzi, V.; Rubini, C.; Lo Muzio, L.
Nicotinamide N-methyltransferase upregulation correlates with tumour differentiation in oral squamous cell carcinoma
Histol. Histopathol.
25
15-20
2010
Homo sapiens
Dostalek, M.; Hardy, K.D.; Milne, G.L.; Morrow, J.D.; Chen, C.; Gonzalez, F.J.; Gu, J.; Ding, X.; Johnson, D.A.; Johnson, J.A.; Martin, M.V.; Guengerich, F.P.
Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems
J. Biol. Chem.
283
17147-17157
2008
Mus musculus, Rattus norvegicus, Mus musculus C57BL/6
Tomida, M.; Mikami, I.; Takeuchi, S.; Nishimura, H.; Akiyama, H.
Serum levels of nicotinamide N-methyltransferase in patients with lung cancer
J. Cancer Res. Clin. Oncol.
135
1223-1229
2009
Homo sapiens
Wu, Y.; Siadaty, M.S.; Berens, M.E.; Hampton, G.M.; Theodorescu, D.
Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration
Oncogene
27
6679-6689
2008
Homo sapiens
Mateuszuk, L.; Khomich, T.I.; Slominska, E.; Gajda, M.; Wojcik, L.; Lomnicka, M.; Gwozdz, P.; Chlopicki, S.
Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis
Pharmacol. Rep.
61
76-85
2009
Mus musculus, Mus musculus C57/BL6J
Kim, H.C.; Mofarrahi, M.; Vassilakopoulos, T.; Maltais, F.; Sigala, I.; Debigare, R.; Bellenis, I.; Hussain, S.N.
Expression and functional significance of nicotinamide N-methyl transferase in skeletal muscles of patients with chronic obstructive pulmonary disease
Am. J. Respir. Crit. Care Med.
181
797-805
2010
Homo sapiens
Parsons, R.B.; Aravindan, S.; Kadampeswaran, A.; Evans, E.A.; Sandhu, K.K.; Levy, E.R.; Thomas, M.G.; Austen, B.M.; Ramsden, D.B.
The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors
Biochem. J.
436
145-155
2011
Homo sapiens
Peng, Y.; Sartini, D.; Pozzi, V.; Wilk, D.; Emanuelli, M.; Yee, V.C.
Structural basis of substrate recognition in human nicotinamide N-methyltransferase
Biochemistry
50
7800-7808
2011
Homo sapiens (P40261), Homo sapiens
Sartini, D.; Pozzi, V.; Renzi, E.; Morganti, S.; Rocchetti, R.; Rubini, C.; Santarelli, A.; Lo Muzio, L.; Emanuelli, M.
Analysis of tissue and salivary nicotinamide N-methyltransferase in oral squamous cell carcinoma: basis for the development of a noninvasive diagnostic test for early-stage disease
Biol. Chem.
393
505-511
2012
Homo sapiens
Tang, S.W.; Yang, T.C.; Lin, W.C.; Chang, W.H.; Wang, C.C.; Lai, M.K.; Lin, J.Y.
Nicotinamide N-methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells
Carcinogenesis
32
138-145
2011
Homo sapiens
Xie, X.; Yu, H.; Wang, Y.; Zhou, Y.; Li, G.; Ruan, Z.; Li, F.; Wang, X.; Liu, H.; Zhang, J.
Nicotinamide N-methyltransferase enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells
Arch. Biochem. Biophys.
564
52-66
2014
Homo sapiens
Liu, K.Y.; Mistry, R.J.; Aguirre, C.A.; Fasouli, E.S.; Thomas, M.G.; Klamt, F.; Ramsden, D.B.; Parsons, R.B.
Nicotinamide N-methyltransferase increases complex I activity in SH-SY5Y cells via sirtuin 3
Biochem. Biophys. Res. Commun.
467
491-496
2015
Homo sapiens
Sartini, D.; Seta, R.; Pozzi, V.; Morganti, S.; Rubini, C.; Zizzi, A.; Tomasetti, M.; Santarelli, L.; Emanuelli, M.
Role of nicotinamide N-methyltransferase in non-small cell lung cancer: in vitro effect of shRNA-mediated gene silencing on tumourigenicity
Biol. Chem.
396
225-234
2015
Homo sapiens
Bi, H.C.; Pan, Y.Z.; Qiu, J.X.; Krausz, K.W.; Li, F.; Johnson, C.H.; Jiang, C.T.; Gonzalez, F.J.; Yu, A.M.
N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis
Carcinogenesis
35
2264-2272
2014
Homo sapiens
Sartini, D.; Morganti, S.; Guidi, E.; Rubini, C.; Zizzi, A.; Giuliante, R.; Pozzi, V.; Emanuelli, M.
Nicotinamide N-methyltransferase in non-small cell lung cancer: promising results for targeted anti-cancer therapy
Cell Biochem. Biophys.
67
865-873
2013
Homo sapiens
Thomas, M.G.; Saldanha, M.; Mistry, R.J.; Dexter, D.T.; Ramsden, D.B.; Parsons, R.B.
Nicotinamide N-methyltransferase expression in SH-SY5Y neuroblastoma and N27 mesencephalic neurones induces changes in cell morphology via ephrin-B2 and Akt signalling
Cell Death Dis.
4
e669
2013
Homo sapiens
Yu, T.; Wang, Y.T.; Chen, P.; Li, Y.H.; Chen, Y.X.; Zeng, H.; Yu, A.M.; Huang, M.; Bi, H.C.
Effects of nicotinamide N-methyltransferase on PANC-1 cells proliferation, metastatic potential and survival under metabolic stress
Cell. Physiol. Biochem.
35
710-721
2015
Homo sapiens
Mori, Y.; Sugawara, A.; Tsuji, M.; Kakamu, T.; Tsuboi, S.; Kanda, H.; Hayakawa, T.; Fukushima, T.
Toxic effects of nicotinamide methylation on mouse brain striatum neuronal cells and its relation to manganese
Environ. Health Prev. Med.
17
371-376
2012
Mus musculus
Milani, Z.H.; Ramsden, D.B.; Parsons, R.B.
Neuroprotective effects of nicotinamide N-methyltransferase and its metabolite 1-methylnicotinamide
J. Biochem. Mol. Toxicol.
27
451-456
2013
Homo sapiens
Patel, M.; Vasaya, M.M.; Asker, D.; Parsons, R.B.
HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples: evidence for substrate inhibition kinetics
J. Chromatogr. B
921-922
87-95
2013
Oryctolagus cuniculus, Homo sapiens, Mus musculus
Hong, S.; Moreno-Navarrete, J.M.; Wei, X.; Kikukawa, Y.; Tzameli, I.; Prasad, D.; Lee, Y.; Asara, J.M.; Fernandez-Real, J.M.; Maratos-Flier, E.; Pissios, P.
Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization
Nat. Med.
21
887-894
2015
Mus musculus, Mus musculus C57Bl6/J
Win, K.T.; Lee, S.W.; Huang, H.Y.; Lin, L.C.; Lin, C.Y.; Hsing, C.H.; Chen, L.T.; Li, C.F.
Nicotinamide N-methyltransferase overexpression is associated with Akt phosphorylation and indicates worse prognosis in patients with nasopharyngeal carcinoma
Tumour Biol.
34
3923-3931
2013
Homo sapiens
Swaminathan, S.; Birudukota, S.; Thakur, M.K.; Parveen, R.; Kandan, S.; Juluri, S.; Shaik, S.; Anand, N.N.; Burri, R.R.; Kristam, R.; Hallur, M.S.; Rajagopal, S.; Schreuder, H.; Langer, T.; Rudolph, C.; Ruf, S.; Dhakshinamoorthy, S.; Gosu, R.; Kannt, A.
Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide
Biochem. Biophys. Res. Commun.
491
416-422
2017
Macaca mulatta (F7ERX8), Mus musculus (O55239), Mus musculus
Thomas, M.G.; Sartini, D.; Emanuelli, M.; van Haren, M.J.; Martin, N.I.; Mountford, D.M.; Barlow, D.J.; Klamt, F.; Ramsden, D.B.; Reza, M.; Parsons, R.B.
Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous beta-carboline norharman evidence for a novel detoxification pathway
Biochem. J.
473
3253-3267
2016
Homo sapiens (P40261)
Loring, H.S.; Thompson, P.R.
Kinetic mechanism of nicotinamide N-methyltransferase
Biochemistry
57
5524-5532
2018
Homo sapiens (P40261), Homo sapiens
Hong, S.; Zhai, B.; Pissios, P.
Nicotinamide N-methyltransferase interacts with enzymes of the methionine cycle and regulates methyl donor metabolism
Biochemistry
57
5775-5779
2018
Mus musculus (O55239), Mus musculus
Ruf, S.; Hallur, M.S.; Anchan, N.K.; Swamy, I.N.; Murugesan, K.R.; Sarkar, S.; Narasimhulu, L.K.; Putta, V.P.R.K.; Shaik, S.; Chandrasekar, D.V.; Mane, V.S.; Kadnur, S.V.; Suresh, J.; Bhamidipati, R.K.; Singh, M.; Burri, R.R.; Kristam, R.; Schreuder, H.; Czech, J.; Rudolph, C.; Marker, A.; Langer, T.; Mullangi,
Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase
Bioorg. Med. Chem. Lett.
28
922-925
2018
Homo sapiens (P40261)
Li, Q.; He, M.D.; Mao, L.; Wang, X.; Jiang, Y.L.; Li, M.; Lu, Y.H.; Yu, Z.P.; Zhou, Z.
Nicotinamide N-methyltransferase suppression participates in nickel-induced histone H3 lysine9 dimethylation in BEAS-2B cells
Cell. Physiol. Biochem.
41
2016-2026
2017
Homo sapiens (P40261), Homo sapiens
Kannt, A.; Pfenninger, A.; Teichert, L.; Toenjes, A.; Dietrich, A.; Schoen, M.R.; Kloeting, N.; Blueher, M.
Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance
Diabetologia
58
799-808
2015
Homo sapiens (P40261)
van Haren, M.J.; Thomas, M.G.; Sartini, D.; Barlow, D.J.; Ramsden, D.B.; Emanuelli, M.; Klamt, F.; Martin, N.I.; Parsons, R.B.
The kinetic analysis of the N-methylation of 4-phenylpyridine by nicotinamide N-methyltransferase Evidence for a novel mechanism of substrate inhibition
Int. J. Biochem. Cell Biol.
98
127-136
2018
Homo sapiens (P40261), Homo sapiens
Neelakantan, H.; Wang, H.Y.; Vance, V.; Hommel, J.D.; McHardy, S.F.; Watowich, S.J.
Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase
J. Med. Chem.
60
5015-5028
2017
Homo sapiens (P40261)
Babault, N.; Allali-Hassani, A.; Li, F.; Fan, J.; Yue, A.; Ju, K.; Liu, F.; Vedadi, M.; Liu, J.; Jin, J.
Discovery of bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT)
J. Med. Chem.
61
1541-1551
2018
Homo sapiens (P40261), Homo sapiens
Chen, D.; Li, L.; Diaz, K.; Iyamu, I.D.; Yadav, R.; Noinaj, N.; Huang, R.
Novel propargyl-linked bisubstrate analogues as tight-binding inhibitors for nicotinamide N-methyltransferase
J. Med. Chem.
62
10783-10797
2019
Homo sapiens (P40261)
Gao, Y.; van Haren, M.J.; Moret, E.E.; Rood, J.J.M.; Sartini, D.; Salvucci, A.; Emanuelli, M.; Craveur, P.; Babault, N.; Jin, J.; Martin, N.I.
Bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT) with enhanced activity
J. Med. Chem.
62
6597-6614
2019
Homo sapiens (P40261), Homo sapiens
Policarpo, R.L.; Decultot, L.; May, E.; Kuzmic, P.; Carlson, S.; Huang, D.; Chu, V.; Wright, B.A.; Dhakshinamoorthy, S.; Kannt, A.; Rani, S.; Dittakavi, S.; Panarese, J.D.; Gaudet, R.; Shair, M.D.
High-affinity alkynyl bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT)
J. Med. Chem.
62
9837-9873
2019
Homo sapiens (P40261)
You, Z.; Liu, Y.; Liu, X.
Nicotinamide N-methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1
Oncol. Lett.
15
9195-9201
2018
Homo sapiens (P40261), Homo sapiens
Hah, Y.; Cho, H.; Jo, S.; Park, Y.; Yoon, T.; Heo, E.
Nicotinamide N-methyltransferase induces the proliferation and invasion of squamous cell carcinoma cells
Oncol. Rep.
42
1805-1814
2019
Homo sapiens (P40261)
Xie, X.; Liu, H.; Wang, Y.; Zhou, Y.; Yu, H.; Li, G.; Ruan, Z.; Li, F.; Wang, X.; Zhang, J.
Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway
Oncotarget
7
45837-45848
2016
Homo sapiens (P40261), Homo sapiens
van Haren, M.J.; Taig, R.; Kuppens, J.; Sastre Torano, J.; Moret, E.E.; Parsons, R.B.; Sartini, D.; Emanuelli, M.; Martin, N.I.
Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state
Org. Biomol. Chem.
15
6656-6667
2017
Homo sapiens (P40261)
Schmeisser, K.; Parker, J.
Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy
PLoS Genet.
14
e1007561
2018
Caenorhabditis elegans (P34254)
html completed
