2.1.1.102: demethylmacrocin O-methyltransferase

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For detailed information about demethylmacrocin O-methyltransferase, go to the full flat file.

Reaction

Synonyms

demethylmacrocin methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.102 demethylmacrocin O-methyltransferase

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Results	in table
31	AA Sequence
1	Application
1	CAS Registry Number
15	Inhibitors
12	Ki Value [mM]
3	KM Value [mM]
1	Metals/Ions
2	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
1	Organism
4	Pathway
1	pH Optimum
1	Purification (Commentary)
1	Reaction
1	Reaction Type
1	Reference
1	Specific Activity [micromol/min/mg]
1	Storage Stability
4	Substrates and Products (Substrate)
1	Subunits
1	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.1.1.102 - demethylmacrocin O-methyltransferase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:demethylmacrocin 2'''-O-methyltransferase

Requires Mg2+. The enzyme, isolated from the bacterium Streptomyces fradiae, is involved in the biosynthesis of the macrolide antibiotic tylosin. The 2-hydroxy group of a 6-deoxy-D-allose moiety in demethylmacrocin acts as the methyl acceptor. Also acts on demethyllactenocin, giving lactenocin. Not identical with EC 2.1.1.101 macrocin O-methyltransferase.