2.1.1.106: tryptophan 2-C-methyltransferase

This is an abbreviated version!
For detailed information about tryptophan 2-C-methyltransferase, go to the full flat file.

Reaction

Synonyms

S-adenosylmethionine:tryptophan 2-methyltransferase, thiostrepton A tryptophan methyltransferase, thiostrepton tryptophan methyltransferase, tryptophan 2-methyltransferase, TsrM, TsrT

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.106 tryptophan 2-C-methyltransferase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
27	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
4	Cofactor
1	General Information
2	Inhibitors
1	Ki Value [mM]
1	KM Value [mM]
1	Localization
2	Metals/Ions
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
4	Organism
1	pH Optimum
1	pH Range
1	Purification (Commentary)
1	Reaction
1	Reaction Type
4	Reference
5	Specific Activity [micromol/min/mg]
1	Storage Stability
12	Substrates and Products (Substrate)
1	Subunits
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]

Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Substrates Products on EC 2.1.1.106 - tryptophan 2-C-methyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Substrate/Product Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-methionine + 3-methylindole

S-adenosyl-L-homocysteine + ?

Streptomyces laurentii

C0JRZ9

-

757761

-

-

?

S-adenosyl-L-methionine + D,L-tryptophan

S-adenosyl-L-homocysteine + D,L-2-methyltryptophan

Streptomyces laurentii

-

significant slower reaction rate with D-tryptophan

485082

-

485082

?

S-adenosyl-L-methionine + D-tryptophan

S-adenosyl-L-homocysteine + D-2-methyltryptophan

Streptomyces laurentii

C0JRZ9

-

757761

-

-

?

S-adenosyl-L-methionine + L-5-fluoro-tryptophan

S-adenosyl-L-homocysteine + L-5-fluoro-2-methyltryptophan

Streptomyces laurentii

C0JRZ9

-

757761

-

-

?

S-adenosyl-L-methionine + L-5-hydroxy-tryptophan

S-adenosyl-L-homocysteine + L-5-hydroxy-2-methyltryptophan

Streptomyces laurentii

C0JRZ9

-

757761

-

-

?

S-adenosyl-L-methionine + L-5-methyl-tryptophan

S-adenosyl-L-homocysteine + L-2,5-dimethyltryptophan

Streptomyces laurentii

C0JRZ9

-

757761

-

-

?

S-adenosyl-L-methionine + L-tryptophan

S-adenosyl-L-homocysteine + L-2-methyltryptophan

Streptomyces laurentii

C0JRZ9

-

734748, 757761

-

-

?

S-adenosyl-L-methionine + melatonin

S-adenosyl-L-homocysteine + ?

Streptomyces laurentii

C0JRZ9

-

757761

-

-

?

S-adenosyl-L-methionine + serotonin

S-adenosyl-L-homocysteine + ?

Streptomyces laurentii

C0JRZ9

-

757761

-

-

?

additional information

?

-

2 entries

additional information

?

-

Streptomyces laurentii

C0JRZ9

no activity with methylcobalamin

734748

-

-

?

additional information

?

-

Streptomyces laurentii

C0JRZ9

TsrM does not catalyse substrate H-atom abstraction but probably exploits a radical-based C-methylation mechanism. TsrM catalyzes methyl transfer to all Trp derivatives tested that are substituted on the indole ring

757761

-

-

-