2.1.1.115: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

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For detailed information about (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase, go to the full flat file.

Reaction

(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline

N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline

Synonyms

(R,S)-Tetrahydrobenzylisoquinoline-N-methyltransferase, Methyltransferase, tetrahydrobenzylisoquinoline, NMT, Norreticuline N-methyltransferase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.115 (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

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Results	in table
1	AA Sequence
1	Application
1	CAS Registry Number
2	General Stability
12	KM Value [mM]
3	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
33	Organism
2	Pathway
8	PDB ID
2	pH Optimum
1	Purification (Commentary)
1	Reaction
1	Reaction Type
33	Reference
1	Source Tissue
1	Storage Stability
19	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 2.1.1.115 - (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

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S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

Broad substrate specificity for (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinolines; including coclaurine, norcoclaurine, isococlaurine, norarmepavine, norreticuline and tetrahydropapaverine. Both R- and S-enantiomers are methylated. The enzyme participates in the pathway leading to benzylisoquinoline alkaloid synthesis in plants. The physiological substrate is likely to be coclaurine. The enzyme was earlier termed norreticuline N-methyltransferase. However, norreticuline has not been found to occur in nature and that name does not reflect the broad specificity of the enzyme for (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinolines.