2.1.1.132: precorrin-6B C5,15-methyltransferase (decarboxylating)

This is an abbreviated version!
For detailed information about precorrin-6B C5,15-methyltransferase (decarboxylating), go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

= 2 S-adenosyl-L-homocysteine +

Synonyms

CobL, GenBank L12005-derived protein, Genbank L12006-derived protein, GenBank U67594-derived protein GI 1500413, Gene cbiE precorrin 6y methylase, Gene cbiT precorrin methylase, Methyltransferase precorrin 6y (Salmonella typhimurium strain LT2 gene cbiE), methyltransferase, precorrin 6y, Methyltransferase, precorrin 6y (Methanococcus jannaschii), Methyltransferase, precorrin 6y (Salmonella typhimurium strain LT2 gene cbiT), Precorrhin-6y methyltransferase, Precorrin-6 methyltransferase, Precorrin-6Y methylase, precorrin-6y methyltransferase, precorrin-8w decarboxylase, Protein (Salmonella typhimurium clone pJO gene cbiE reduced), Protein (Salmonella typhimurium clone pJO26 gene cbiT reduced)

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.132 precorrin-6B C5,15-methyltransferase (decarboxylating)

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Results	in table
1964	AA Sequence
7	CAS Registry Number
3	Cloned(Commentary)
1	Crystallization (Commentary)
1	KM Value [mM]
6	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
10	Organism
4	Pathway
10	PDB ID
2	Purification (Commentary)
5	Reaction
1	Reaction Type
9	Reference
1	Specific Activity [micromol/min/mg]
16	Substrates and Products (Substrate)
7	Subunits
17	Synonyms
1	Systematic Name

Reference

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Reference on EC 2.1.1.132 - precorrin-6B C5,15-methyltransferase (decarboxylating)

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3208

Roth, J.R.; Lawrence, J.G.; Rubenfield, M.; Kieffer-Higgins, S.; Church, G.M.

Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium

J. Bacteriol.

175

3303-3316

1993

Pseudomonas denitrificans (nom. rej.), Salmonella enterica subsp. enterica serovar Typhimurium

8501034

3209

Roessner, C.A.; Spencer, J.B.; Ozaki, S.; Min, C.; Atshaves, B.P.; Nayar, P.; Anousis, N.; Stolowich, N.J.; Holderman, M.T.; Scott, A.I.

Overexpression in Escherichia coli of 12 vitamin B12 biosynthetic enzymes

Protein Expr. Purif.

155-163

1995

Pseudomonas denitrificans (nom. rej.)

7606163

3211

Crouzet, J.; Cameron, B.; Cauchois, L.; Rigault, S.; Rouyez, M.C.; Blanche, F.; Thibaut, D.; Debussche, L.

Genetic and sequence analysis of an 8.7-kilobase Pseudomonas denitrificans fragment carrying eight genes involved in transformation of precorrin-2 to cobyrinic acid

J. Bacteriol.

172

5980-5990

1990

Pseudomonas denitrificans (nom. rej.)

2211521

15273

Blanche, F.; Famechon, A.; Thibaut, D.; Debussche, L.; Cameron, B.; Crouzet, J.

Biosynthesis of vitamin B12 in Pseudomonas denitrificans: the biosynthetic sequence from precorrin-6y to precorrin-8x is catalyzed by the cobL gene product

J. Bacteriol.

174

1050-1052

1992

Pseudomonas denitrificans (nom. rej.), Pseudomonas denitrificans (nom. rej.) SC510 Rif

1732195

659875

Roessner, C.A.; Huang, K.X.; Warren, M.J.; Raux, E.; Scott, A.I.

Isolation and characterization of 14 additional genes specifying the anaerobic biosynthesis of cobalamin (vitamin B12) in Propionibacterium freudenreichii (P. Shermanii)

Microbiology

148

1845-1853

2002

Propionibacterium freudenreichii, Pseudomonas denitrificans (nom. rej.)

12055304

660514

Keller, J.P.; Smith, P.M.; Benach, J.; Christendat, D.; de Titta, G.T.; Hunt, J.F.

The crystal structure of MT0146/CbiT suggests that the putative precorrin-8w decarboxylase is a methyltransferase

Structure

1475-1487

2002

Methanothermobacter thermautotrophicus

12429089