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2.1.1.133: precorrin-4 C11-methyltransferase

This is an abbreviated version!
For detailed information about precorrin-4 C11-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
precorrin-4
=
S-adenosyl-L-homocysteine
+
precorrin-5

Synonyms

Cobalt-precorrin-4 methyltransferase, Methyltransferase (Pseudomonas denitrificans clone pXL151 gene cobF reduced), Methyltransferase, precorrin 2- (Pseudomonas denitrificans clone pXL151), Precorrin-3 methylase, Protein (Pseudomonas denitrificans clone pXL151 gene cobF reduced), S-Adenosyl-L-methionine-dependent cobalt-precorrin-4 transmethylase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.133 precorrin-4 C11-methyltransferase

Systematic Name

Systematic Name on EC 2.1.1.133 - precorrin-4 C11-methyltransferase

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SYSTEMATIC NAME
IUBMB Comments
S-Adenosyl-L-methionine:precorrin-4 C11 methyltransferase
In the aerobic (late cobalt insertion) cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5, and precorrin-6A, respectively. See EC 2.1.1.271, cobalt-precorrin-4 methyltransferase, for the C11-methyltransferase enzyme that participates in the anaerobic cobalamin biosynthesis pathway.