2.1.1.139: 3'-demethylstaurosporine O-methyltransferase

This is an abbreviated version!
For detailed information about 3'-demethylstaurosporine O-methyltransferase, go to the full flat file.

Reaction

Synonyms

3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase, staurosporine synthase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.139 3'-demethylstaurosporine O-methyltransferase

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Results	in table
1	Activating Compound
1	CAS Registry Number
7	Inhibitors
2	Natural Substrates/ Products (Substrates)
2	Organism
4	Pathway
1	Purification (Commentary)
1	Reaction
1	Reaction Type
2	Reference
1	Storage Stability
2	Substrates and Products (Substrate)
2	Synonyms
1	Systematic Name

Inhibitors

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Inhibitors on EC 2.1.1.139 - 3'-demethylstaurosporine O-methyltransferase

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1H-indole

Streptomyces longisporoflavus

62% activity left at 1.1 mM

288658

3'-demethylstaurosporine

Streptomyces longisporoflavus

69% activity at 1.1 mM

288658

anthranilate

Streptomyces longisporoflavus

75% activity left at 1.1 mM

288658

Indole-3-pyruvate

Streptomyces longisporoflavus

44% activity left at 1.1 mM

288658

S-(5'-adenosyl)-L-homocysteine

Streptomyces longisporoflavus

strong inhibition, 8% activity left at 1.1 mM, probably competitive inhibition

288658

sinefungin

Lentzea albida

antiprotozoal antibiotic from Streptomyces griseolus, efficient inhibition with concentrations higher than 1 mg/100 ml

288657

tryptophan

Streptomyces longisporoflavus

64% activity left at 1.1 mM

288658