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2.1.1.142: cycloartenol 24-C-methyltransferase

This is an abbreviated version!
For detailed information about cycloartenol 24-C-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.142

Reaction

S-adenosyl-L-methionine
+
5alpha-cholesta-8,24-dien-3beta-ol
=
S-adenosyl-L-homocysteine
 +
24-methylene-5alpha-cholest-8-en-3beta-ol

Synonyms

(S)-adenosyl-L-methionine-DELTA24-sterol methyltransferase, (S)-adenosyl-L-methionine:DELTA24(25)-sterol methyltransferase, 24-SMT, C-24-methyltransferase, C24-sterol methyltransferase type 1, DELTA24(25)-sterol methyltransferase, DELTA24-sterol methyltransferase, Erg6, GhSMT2-1, GhSMT2-2, More, SAM-DELTA24 sterol transmethylase, SAM:SMT, SMT, SMT protein, SMT-2, SMT-3, SMT1, SMT2, SMT2-1, sterol 24-C methyltransferase, sterol 24C-methyltransferases, sterol C-24 methyltransferase, sterol C-24-methyltransferase, sterol C-methyltransferase, sterol C24-methyltransferase, sterol methyl transferase, sterol methyltransferase, sterol methyltransferase2, zymosterol-24(25)-methyltransferase, zymosterol-24-methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.142 cycloartenol 24-C-methyltransferase

Inhibitors

Inhibitors on EC 2.1.1.142 - cycloartenol 24-C-methyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(24R)-24-methyl-25,26,27-trisnor-24-dimethylamino-N-oxide cycloartenol
-
-
(24R)-24-methyl-25-azacycloartenol
-
-
(24R,S)-24-Ethyl-25-azacycloartenol
-
-
(24R,S)-24-Methyl-25,26,27-trisnor-24-dimethylamino-N-oxide cycloartenol
-
-
(24R,S)-24-Methyl-25,26,27-trisnor-24-dimethylsulfonium cycloartenol iodide
-
-
(24R,S)-24-Methyl-25,26,27-trisnor-24-trimethylarsonium cycloartenol iodide
-
-
(24R,S)-24-Methyl-25-azacycloartenol
-
-
(24S)-24-methyl-25,26,27-trisnor-24-dimethylamino-N-oxide cycloartenol
-
-
(24S)-24-methyl-25-azacycloartenol
-
-
(3beta24R,S)-24-methyl-24-thionacycloart-3-ol iodide
-
reversible, non-competitive-type
23-Azacholesterol
-
-
24(28)-methylene cycloartanol
competitive
24(28)-methylenecycloartanol
24(28)-methylenecycloartenol
-
-
24(28)-methylenencycloartanol
-
-
24,25-dehydro-27-methenyl-cycloartenol
-
i.e. cycloartenol nucleus substrate analogue with double bond at C8
24,25-dehydro-27-methylene-cycloartenol
-
i.e. cycloartenol nucleus substrate analogue with double bond at C14, non-competitive
24-Azacholesterol
-
-
24-Azacycloartanyl acetate
-
-
24-bromocycloartenol
-
competitive; competitive inhibitor relative to cycloartenol; time-dependent inhibition kinetics
24-dehydrocycloartenol
-
a mechanism-based inactivator
24-fluorocycloartenol
-
allylic substrate analog, time-dependent inhibition kinetics, consistent with the action of a suicide substrate that irreversibly inactivates the enzyme; competitive, the electron-withdrawing alpha-fluorine substituent suppresses the rate of the C-methylation reaction
24-Methyl-25,26,27-trisnor-24-trimethylammonium cycloartenol iodide
-
24R and 24S isomer
24-Methyl-25-azacycloartenol
-
24R and 24S isomer
24-methyl-9,19-cyclolanost-24-en-3-ol
-
i.e. cyclobranol, competitive
24-Oxo-25-azacycloartenol
-
-
24-thiacycloartanol
24-thiacycloartenol
-
-
24beta-methylcycloartanol
-
competitive with cycloartenol
25,26,27-Trisnor-24-trimethylammonium cycloartenol iodide
-
-
25-Azacholesterol
-
-
25-azacycloartanol
non-competitive
25-Azacycloartenol
25-azacyloartenol
-
25-azalanosterol
-
substrate analogue, competitive-type inhibitor, a potent inhibitor of cell growth promoting lanosterol accumulation and 24-alkyl sterol depletion
26,27-dehydrocycloartenol
-
-
26,27-dehydrolanosterol
-
substrate analogue, competitive-type inhibitor, pseudofirst-order, time-dependent inactivation of the PbSMT. Formation of a reversibly bound enzyme-substrate complex, followed by catalysis to an intermediate that can be converted to a methyl product or the intermediate can be intercepted through covalent modification and hence irreversible inhibition, lanosterol or 26,27-dehydrolanosterol can lead to distinct intermediates that convert to methylated sterol products
26,27-dehydrozymosterol
-
mechanism-based inhibitor, specific covalent modification of SMT2
26-difluorocycloartenol
-
competitive inhibitor
26-fluorocycloartenol
-
competitive inhibitor
26-methenylcycloartenol
-
pseudo-first-order time-dependent inactivation, less potency of inhibition
26-methynylcycloartenol
-
inhibition kinetics non-competitive and time-dependent, less potency of inhibition
citrostadienol
-
competitive with cycloartenol or 24(28)-methylenelophenol
cycloarta-24,26-dienol
-
-
Cycloartenol
-
-
cyclobranol
-
competitive-type inhibitor
cyclolaudanol
-
-
cyclolaudenol
-
dead end inhibitor analog, competitive versus cycloartenol, uncompetitive versus S-adenosyl-L-methionine
S-adenosyl-L-homocysteine
-
noncompetitive with respect to S-adenosyl-L-methionine
sitosterol
additional information
-