Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.1.1.157: sarcosine/dimethylglycine N-methyltransferase

This is an abbreviated version!
For detailed information about sarcosine/dimethylglycine N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.157

Reaction

2 S-adenosyl-L-methionine +

sarcosine
= 2 S-adenosyl-L-homocysteine +
betaine

Synonyms

dimethylglycine methyltransferase, DMT, DMT2, glycine sarcosine dimethylglycine methyltransferase, glycine sarcosine methyltransferase, GSDMT, GsSDMT, MXAN 3190, sarcosine dimethylglycine methyltransferas, sarcosine dimethylglycine methyltransferase, sarcosine dimethylglycine N-methyltransferase, Sdm, Sdm homologue protein, SdmA, SDMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.157 sarcosine/dimethylglycine N-methyltransferase

Cloned

Cloned on EC 2.1.1.157 - sarcosine/dimethylglycine N-methyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination, the single gene encodes the sarcosine dimethylglycine methyltransferase as well as the glycine sarcosine methyltransferase, EC 2.1.1.156, the first being probably a proteolytic processing product of the latter, functional expression of a truncated soluble enzyme form in Escherichia coli
-
expressed in Anabaena doliolum
-
expressed in Anabaena sp. PCC7120
expressed in Oryza sativa cultivar Nipponbare
expressed in Zea mays
-
expression in Escherichia coli
functional overexpression in Escherichia coli strain XL-1 Blue conferring betaine accumulation and increased salt tolerance when coexpressed with the glycine sarcosine methyltransferase, EC 2.1.1.156
-
gene Mpsdmt, DNA and amino acid sequence determination and analysis and sequence comparisons, phylogenetic analysis of SDMT, expression of complete gene cluster of Mpgsmt-sdmt in Escherichia coli strain BL21(DE3) and in strain MKH13 deficient in betaine transport, the recombinant enzyme is functional to synthesize and accumulate betaine and confers elevated survival ability in betaine transport deficient mutant strain MKH13 under high salt stress
gene sdmA, DNA and amino acid sequence determination and analysis, sequence comparison
-
orf2, DNA and amino acid sequence determination and analysis, phylogenetic analysis, overexpression of wild-type and mutant enzymes in Escherichia coli, functional coexpression of the soluble enzyme with the glycine sarcosine methyltransferase, EC 2.1.1.156, increases the intracellular betaine level and the growth rate of Escherichia coli strain BL21(DE3)