2.1.1.159: theobromine synthase
This is an abbreviated version!
For detailed information about theobromine synthase, go to the full flat file.
Word Map on EC 2.1.1.159
-
2.1.1.159
-
purine
-
camellia
-
xanthosine
-
coffea
-
1,3,7-trimethylxanthine
-
arabica
-
n-methyltransferases
-
caffeine-free
-
rnai
-
food industry
-
planta
-
canephora
-
germplasms
-
sinensis
-
biotechnology
-
agriculture
- 2.1.1.159
- purine
- camellia
- xanthosine
- coffea
- 1,3,7-trimethylxanthine
- arabica
- n-methyltransferases
-
caffeine-free
- rnai
- food industry
-
planta
- canephora
-
germplasms
- sinensis
- biotechnology
- agriculture
Reaction
Synonyms
3,7-dimethylxanthine methyltransferase, 3-N-methyltransferase, 3NMT, 7-methylxanthine 3-N-methyltransferase, 7-methylxanthine methyltransferase, 7-methylxanthine N-methyltransferase, caffeine synthase, caffeine synthase 1, CCS1, coffee caffeine synthase 1, CS, CtCS6, CTS, CTS1, CTS2, DXMT, DXMT1, MXMT, MXMT1, MXMT2, N-3 methyltransferase, N-methyltransferase, TCS1, theobromine synthase 2
ECTree
2.1.1.159 theobromine synthaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.1.1.159 - theobromine synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 1,7-dimethylxanthine
S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
-
i.e. paraxanthine
i.e. caffeine
-
?
S-adenosyl-L-methionine + 1-methylxanthine
S-adenosyl-L-homocysteine + 1,3-dimethylxanthine
S-adenosyl-L-methionine + 3,7-dimethylxanthine
S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
S-adenosyl-L-methionine + 3-methylxanthine
S-adenosyl-L-homocysteine + 1,3-dimethylxanthine
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine + H+
S-adenosyl-L-methionine + paraxanthine
S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
S-adenosyl-L-methionine + 1-methylxanthine
S-adenosyl-L-homocysteine + 1,3-dimethylxanthine
-
low activity
i.e. theophylline
-
?
S-adenosyl-L-methionine + 1-methylxanthine
S-adenosyl-L-homocysteine + 1,3-dimethylxanthine
low activity with the recombinant enzyme, poor activity with the native enzyme
i.e. theophylline
-
?
S-adenosyl-L-methionine + 3,7-dimethylxanthine
S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
-
reaction of EC 2.1.1.160
i.e. caffeine
-
?
S-adenosyl-L-methionine + 3,7-dimethylxanthine
S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
reaction of EC 2.1.1.160
i.e. caffeine
-
?
S-adenosyl-L-methionine + 3,7-dimethylxanthine
S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
-
-
i.e. caffeine
-
?
S-adenosyl-L-methionine + 3,7-dimethylxanthine
S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
-
i.e. caffeine
-
?
S-adenosyl-L-methionine + 3,7-dimethylxanthine
S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
-
-
i.e. caffeine
-
?
S-adenosyl-L-methionine + 3-methylxanthine
S-adenosyl-L-homocysteine + 1,3-dimethylxanthine
-
low activity
i.e. theophylline
-
?
S-adenosyl-L-methionine + 3-methylxanthine
S-adenosyl-L-homocysteine + 1,3-dimethylxanthine
poor activity with the recombinant enzyme, low activity with the native enzyme
i.e. theophylline
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
-
-
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
-
i.e. theobromine
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
i.e. theobromine
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
the enzyme is part of a caffeine biosynthetic pathway which includes a recycling of adenosine released from S-adenosyl-L-methionine in form of xanthosine monophosphate, overview
i.e. theobromine
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
-
i.e. theobromine
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
i.e. theobromine
-
ir
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
i.e. theobromine
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
i.e. theobromine
-
ir
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
i.e. theobromine
-
ir
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
i.e. theobromine
-
ir
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
Q8H0G0
-
i.e. theobromine
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
second step in caffeine biosynthesis pathway
i.e. theobromine
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
second step in caffeine biosynthesis pathway
i.e. theobromine
-
ir
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
second step in caffeine biosynthesis pathway from xanthosine
i.e. theobromine
-
ir
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
second step in caffeine biosynthesis pathway, theobromine is the major intermediate for caffeine biosynthesis
i.e. theobromine
-
ir
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
Q8H0G0
step of the caffeine biosynthesis, caffeine accumulation in seeds
i.e. theobromine
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
third step in caffeine biosynthesis pathway from xanthosine
i.e. theobromine
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
preferred substrate, 20fold higher activity by isozyme MXMT2 compared to activity with paraxanthine
i.e. theobromine
-
ir
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
preferred substrate, 3fold higher activity by isozyme MXMT1 compared to activity with paraxanthine
i.e. theobromine
-
ir
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
-
-
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
-
i.e. theobromine
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
-
i.e. theobromine
-
ir
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
i.e. theobromine
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
second step in caffeine biosynthesis pathway, theobromine is the major intermediate for caffeine biosynthesis, overview
i.e. theobromine
-
ir
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
step of the caffeine biosynthesis, caffeine accumulation in seeds
i.e. theobromine
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
-
i.e. theobromine
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
Coffea sp.
-
-
-
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
best substrate
i.e. theobromine
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine + H+
-
-
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine + H+
-
-
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine + H+
-
-
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine + H+
-
-
-
?
S-adenosyl-L-methionine + 7-methylxanthine
S-adenosyl-L-homocysteine + 3,7-dimethylxanthine + H+
-
-
-
?
S-adenosyl-L-methionine + paraxanthine
S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
-
best substrate
i.e. caffeine
-
?
S-adenosyl-L-methionine + paraxanthine
S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
best substrate
i.e. caffeine
-
?
S-adenosyl-L-methionine + paraxanthine
S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
-
i.e. caffeine
-
?
S-adenosyl-L-methionine + paraxanthine
S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
-
i.e. caffeine
-
ir
S-adenosyl-L-methionine + paraxanthine
S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
-
i.e. caffeine
-
ir
S-adenosyl-L-methionine + paraxanthine
S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
low activity
i.e. caffeine
-
ir
S-adenosyl-L-methionine + paraxanthine
S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
low activity by isozyme MXMT1
i.e. caffeine
-
ir
S-adenosyl-L-methionine + paraxanthine
S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
low activity by isozyme MXMT2
i.e. caffeine
-
ir
additional information
?
-
no activity with any other substrate containing theophylline and xanthosine. 7-Methylxanthosine is the specific methyl acceptor
-
-
?
additional information
?
-
no activity with any other substrate containing theophylline and xanthosine. 7-Methylxanthosine is the specific methyl acceptor
-
-
?
additional information
?
-
no activity with any other substrate containing theophylline and xanthosine. 7-Methylxanthosine is the specific methyl acceptor
-
-
?
additional information
?
-
no activity with any other substrate containing theophylline and xanthosine. 7-Methylxanthosine is the specific methyl acceptor
-
-
?
additional information
?
-
no activity with any other substrate containing theophylline and xanthosine. 7-Methylxanthosine is the specific methyl acceptor
-
-
?
additional information
?
-
no activity with any other substrate containing theophylline and xanthosine. 7-Methylxanthosine is the specific methyl acceptor
-
-
?
additional information
?
-
the bifunctional enzyme also catalyzes the reaction of the caffeine synthase, EC 2.1.1.160
-
-
?
additional information
?
-
-
the bifunctional enzyme catalyzes the last two steps of the caffeine biosynthesis
-
-
?
additional information
?
-
substrate specificity, overview, the bifunctional enzyme also catalyzes the reaction of the caffeine synthase, EC 2.1.1.160, no activity with xanthosine and theophylline
-
-
?
additional information
?
-
-
substrate specificity, overview, the bifunctional enzyme also catalyzes the reaction of the caffeine synthase, EC 2.1.1.160, no activity with xanthosine, xanthosine 5-phosphate, and theophylline
-
-
?
additional information
?
-
bifunctional enzyme performing 3-N-methyltransferase activity, EC 2.1.1.159, and 1-N-methyltransferase activity, EC 2.1.1.160, overview
-
-
?
additional information
?
-
Q8H0G0
enzyme expression and activity during caffeine biosynthesis in fruits, overview
-
-
?
additional information
?
-
-
feeding experiments with fruit samples, determination of reaction products, overview
-
-
?
additional information
?
-
substrate specificity, bifunctional enzyme performing 3-N-methyltransferase activity, EC 2.1.1.159, and 1-N-methyltransferase activity, EC 2.1.1.160, overview
-
-
?
additional information
?
-
-
substrate specificity, overview, no activity with xanthine, hypoxanthine, and xanthosine
-
-
?
additional information
?
-
-
enzyme expression and activity during caffeine biosynthesis in fruits, overview
-
-
?
additional information
?
-
-
the bifunctional enzyme also catalyzes the reaction of the caffeine synthase, EC 2.1.1.160
-
-
?
additional information
?
-
the bifunctional enzyme also catalyzes the reaction of the caffeine synthase, EC 2.1.1.160
-
-
?
additional information
?
-
-
enzyme expression and activity during caffeine biosynthesis in fruits, overview
-
-
?
additional information
?
-
Coffea sp.
-
minor activity of 3-N-methylation of paraxanthine is present in theobromine synthase
-
-
?
