2.1.1.163: demethylmenaquinone methyltransferase

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For detailed information about demethylmenaquinone methyltransferase, go to the full flat file.

Reaction

Synonyms

2-heptaprenyl-1,4-naphthoquinone methyltransferase, DMK methyltransferase, Dmkt1, DmtH protein, menaquinone biosynthesis methyltransferase, menG, UbiE

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.163 demethylmenaquinone methyltransferase

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Results	in table
32913	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
2	Cofactor
1	Expression
16	General Information
2	Localization
1	Metals/Ions
4	Natural Substrates/ Products (Substrates)
13	Organism
14	Pathway
1	pH Optimum
7	Protein Variants
1	Reaction
11	Reference
1	Source Tissue
7	Substrates and Products (Substrate)
10	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.1.1.163 - demethylmenaquinone methyltransferase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methione:demethylmenaquinone methyltransferase

The enzyme catalyses the last step in menaquinone biosynthesis. It is able to accept substrates with varying polyprenyl side chain length (the chain length is determined by polyprenyl diphosphate synthase)[1]. The enzyme from Escherichia coli also catalyses the conversion of 2-methoxy-6-octaprenyl-1,4-benzoquinone to 5-methoxy-2-methyl-3-octaprenyl-1,4-benzoquinone during the biosynthesis of ubiquinone [4]. The enzyme probably acts on menaquinol rather than menaquinone.