2.1.1.167: 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase

This is an abbreviated version!
For detailed information about 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.167

2.1.1.167

rrnas

nucleolar

2'-o-ribose

pre-ribosomal

coimmunoprecipitation

cold-sensitive

methyltransferases

Reaction

2'-O-methylguanosine2922 in 27S pre-rRNA

Synonyms

Spb1p

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.167 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
3	AA Sequence
1	Cofactor
2	General Information
2	Localization
1	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
4	Organism
11	PDB ID
2	Protein Variants
1	Reaction
4	Reference
6	Substrates and Products (Substrate)
1	Subunits
2	Synonyms
1	Systematic Name

Natural Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Natural Substrates Products on EC 2.1.1.167 - 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Natural Substrate Search

S-adenosyl-L-methionine + guanosine2922 in 27S pre-rRNA

S-adenosyl-L-homocysteine + 2'-O-methylguanosine2922 in 27S pre-rRNA

Saccharomyces cerevisiae

Spb1p is a site-specific 2'-O-ribose RNA MTase that catalyzes the formation of Gm2922, a universally conserved position of the catalytic center of the ribosome that is essential for translation. The enzyme is required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Specifically methylates the guanosine in position 2922 of the 25S rRNA at the stage of 27S pre-rRNA maturation. Methylates also the uridine in position 2921 in the absence of methylation of this residue guided by snoRNA snR52 at the stage of 35S pre-rRNA maturation. 2'-O-methylguanosine2922 appears at a late processing stage, during the maturation of the 27S pre-rRNA

700204

S-adenosyl-L-methionine + uridine2918 in 25S rRNA

S-adenosyl-L-homocysteine + 2'-O-methyluridine2918 in 25S rRNA

2 entries

additional information

2 entries