2.1.1.167: 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase

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For detailed information about 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase, go to the full flat file.

Reaction

Synonyms

Spb1p

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.167 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase

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Results	in table
3	AA Sequence
1	Cofactor
2	General Information
2	Localization
1	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
4	Organism
11	PDB ID
2	Protein Variants
1	Reaction
4	Reference
6	Substrates and Products (Substrate)
1	Subunits
2	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.1.1.167 - 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:27S pre-rRNA (guanosine2922-2'-O)-methyltransferase

Spb1p is a site-specific 2'-O-ribose RNA methyltransferase that catalyses the formation of 2'-O-methylguanosine2922, a universally conserved position of the catalytic center of the ribosome that is essential for translation. 2'-O-Methylguanosine2922 is formed at a later stage of the processing, during the maturation of of the 27S pre-rRNA. In absence of snR52, Spb1p can also catalyse the formation of uridine2921 [1].