2.1.1.168: 21S rRNA (uridine2791-2'-O)-methyltransferase

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For detailed information about 21S rRNA (uridine2791-2'-O)-methyltransferase, go to the full flat file.

Reaction

Synonyms

mitochondrial 21S rRNA methyltransferase, mitochondrial rRNA MTase 2, MRM2

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.168 21S rRNA (uridine2791-2'-O)-methyltransferase

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Results	in table
4	AA Sequence
2	Cloned(Commentary)
1	Cofactor
1	Expression
2	General Information
1	Localization
1	Natural Substrates/ Products (Substrates)
2	Organism
1	Protein Variants
1	Reaction
2	Reference
2	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 2.1.1.168 - 21S rRNA (uridine2791-2'-O)-methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-methionine + uridine2791 in 21S rRNA

S-adenosyl-L-homocysteine + 2'-O-methyluridine2791 in 21S rRNA

2 entries

S-adenosyl-L-methionine + uridine2791 in 21S rRNA

S-adenosyl-L-homocysteine + 2'-O-methyluridine2791 in 21S rRNA

Saccharomyces cerevisiae

P53123

mitochondria of the yeast Saccharomyces cerevisiae assemble their ribosomes from ribosomal proteins, encoded by the nuclear genome (with one exception), and rRNAs of 15S and 21S, encoded by the mitochondrial genome. Unlike cytoplasmic rRNA, which is highly modified, mitochondrial rRNA contains only three modified nucleotides: a pseudouridine and two 2'-O-methylated riboses (Gm2270 and Um2791) located at the peptidyl transferase centre of 21S rRNA. Mrm2 is required for methylating U2791 of 21S rRNA

697605

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S-adenosyl-L-methionine + uridine2791 in 21S rRNA

S-adenosyl-L-homocysteine + 2'-O-methyluridine2791 in 21S rRNA

Saccharomyces cerevisiae

P53123

Mrm2p methylates the 21S rRNA at position U2791 in vitro, when it is assembled with proteins into the ribosomal large subunit ir the precursor of the ribosomal large subunit. NO methylation is observed with deproteinized rRNA

697605

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