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2.1.1.17: phosphatidylethanolamine N-methyltransferase

This is an abbreviated version!
For detailed information about phosphatidylethanolamine N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.17

Reaction

S-adenosyl-L-methionine
+
phosphatidylethanolamine
=
S-adenosyl-L-homocysteine
 +
phosphatidyl-N-methylethanolamine

Synonyms

lipid methyl transferase, LMTase, methyltransferase, phosphatidylethanolamine, PE N-MTase, PE-NMT, PEMT, PEMT shorter isoform, phosphatidylethanolamine methyltransferase, phosphatidylethanolamine N-methyltransferase, phosphatidylethanolamine-N-methylase, phosphatidylethanolamine-N-methyltransferase, phosphatidylethanolamine-S-adenosylmethionine methyltransferase, phospholipid N-methyltransferase, PmtA, PmtX1, PmtX3

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.17 phosphatidylethanolamine N-methyltransferase

Activating Compound

Activating Compound on EC 2.1.1.17 - phosphatidylethanolamine N-methyltransferase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-methyl-4-phenylpyridinium
-
enhances activity. S-Adenosylmethionine hypermethylation can be involved in the etiology of Parkinson‘s disease and an increase of phospholipid methylation could be one of the mechanisms by which 1-methyl-4-phenyl-pyridinium causes parkinsonism
betaine
attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway, the effect is enhanced by ethanol, which alone has no effect on expression levels of the enzyme, overview
ethanol
enhances the inducing and protecting effects of betaine on the enzyme, alone has only a slightly activating effect on the enzyme activity, overview
L-Cys
-
enhances activity, optimal concentration 10 mM
progesterone
-
physiological levels of progesterone activate PE-NMT and sphingomyelin synthase
Triton X-100
-
enhances activity, optimal concentration 0.04%
Tween 20
-
stimulates
additional information
-