2.1.1.17: phosphatidylethanolamine N-methyltransferase
This is an abbreviated version!
For detailed information about phosphatidylethanolamine N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.17
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2.1.1.17
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phosphatidylcholine
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choline
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homocysteine
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cytidylyltransferase
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cdp-choline
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betaine
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s-adenosylhomocysteine
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ctp:phosphocholine
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cdp-diacylglycerol
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phosphatidyl-n,n-dimethylethanolamine
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phosphatidyl-n-monomethylethanolamine
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choline-deficient
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transmethylation
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n-methyltransferases
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kennedy
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adomet
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vance
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phosphatidylmonomethylethanolamine
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medicine
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ptdcho
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analysis
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phosphatidyldimethylethanolamine
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mthfd1
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remethylation
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cholinephosphotransferase
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adohcy
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choline-supplemented
- 2.1.1.17
- phosphatidylcholine
- choline
- homocysteine
- cytidylyltransferase
- cdp-choline
- betaine
- s-adenosylhomocysteine
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ctp:phosphocholine
- cdp-diacylglycerol
- phosphatidyl-n,n-dimethylethanolamine
- phosphatidyl-n-monomethylethanolamine
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choline-deficient
-
transmethylation
- n-methyltransferases
-
kennedy
- adomet
-
vance
- phosphatidylmonomethylethanolamine
- medicine
-
ptdcho
- analysis
- phosphatidyldimethylethanolamine
- mthfd1
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remethylation
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cholinephosphotransferase
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adohcy
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choline-supplemented
Reaction
Synonyms
lipid methyl transferase, LMTase, methyltransferase, phosphatidylethanolamine, PE N-MTase, PE-NMT, PEMT, PEMT shorter isoform, phosphatidylethanolamine methyltransferase, phosphatidylethanolamine N-methyltransferase, phosphatidylethanolamine-N-methylase, phosphatidylethanolamine-N-methyltransferase, phosphatidylethanolamine-S-adenosylmethionine methyltransferase, phospholipid N-methyltransferase, PmtA, PmtX1, PmtX3
ECTree
2.1.1.17 phosphatidylethanolamine N-methyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.1.1.17 - phosphatidylethanolamine N-methyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
2 S-adenosyl-L-homocysteine + phosphatidylcholine
3 S-adenosyl-L-methionine + phosphatidylethanolamine
3 S-adenosyl-L-homocysteine + phosphatidylcholine + 2 H+
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-methionine + phosphatidylethanolamin
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
S-adenosyl-L-homocysteine + phosphatidylcholine
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
2 S-adenosyl-L-homocysteine + phosphatidylcholine
-
-
-
-
?
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
2 S-adenosyl-L-homocysteine + phosphatidylcholine
-
the transfer of a methyl group to phosphatidyl-N-methylethanolamine and phosphatidyl-N,N-dimethylethanolamine is catalyzed by a second enzyme
-
-
?
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
2 S-adenosyl-L-homocysteine + phosphatidylcholine
-
-
-
-
?
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
2 S-adenosyl-L-homocysteine + phosphatidylcholine
-
phospholipid substrates and products are the first to bind and the last to dissociate from the active site
-
-
?
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
2 S-adenosyl-L-homocysteine + phosphatidylcholine
-
the transfer of a methyl group to phosphatidyl-N-methylethanolamine and phosphatidyl-N,N-dimethylethanolamine is catalyzed by a second enzyme
-
-
?
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
2 S-adenosyl-L-homocysteine + phosphatidylcholine
-
ordered bi-bi mechanism
-
-
?
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
2 S-adenosyl-L-homocysteine + phosphatidylcholine
-
the transfer of a methyl group to phosphatidyl-N-methylethanolamine and phosphatidyl-N,N-dimethylethanolamine is catalyzed by a second enzyme
-
-
?
3 S-adenosyl-L-methionine + phosphatidylethanolamine
3 S-adenosyl-L-homocysteine + phosphatidylcholine + 2 H+
-
-
-
?
3 S-adenosyl-L-methionine + phosphatidylethanolamine
3 S-adenosyl-L-homocysteine + phosphatidylcholine + 2 H+
betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway, overview
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-
?
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-methionine + phosphatidylethanolamin
-
-
-
-
?
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-methionine + phosphatidylethanolamin
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
S-adenosyl-L-homocysteine + phosphatidylcholine
-
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline
-
?
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
S-adenosyl-L-homocysteine + phosphatidylcholine
-
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
the transfer of a methyl group to phosphatidyl-N-methylethanolamine and phosphatidyl-N,N-dimethylethanolamine is catalyzed by a second enzyme
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
phospholipid substrates and products are the first to bind and the last to dissociate from the active site
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
the transfer of a methyl group to phosphatidyl-N-methylethanolamine and phosphatidyl-N,N-dimethylethanolamine is catalyzed by a second enzyme
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
ordered bi-bi mechanism
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
the transfer of a methyl group to phosphatidyl-N-methylethanolamine and phosphatidyl-N,N-dimethylethanolamine is catalyzed by a second enzyme
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
expression of PEMT2 in CHO cells does not down-regulate, but rather enhance, the expression of CTP-phosphocholine cytidylyltransferase
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
a decrease in enzyme activity is observed in the frontal cortex of the brain affected with Alzheimers disease
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
the transfer of a methyl group to monomethyl-N-phosphatidylcholine and dimethyl-N,N-phosphatidylcholine is catalyzed by a second enzyme
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
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-
485167, 485168, 485169, 485170, 485171, 485174, 485179, 485180, 485181, 485183, 485184, 485186, 485188, 485189, 485191, 485192, 485195
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-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
transfer of three methyl groups to the amino head group of phosphatidylethanolamine
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
the transfer of a methyl group to monomethyl-N-phosphatidylcholine and dimethyl-N,N-phosphatidylcholine is catalyzed by a second enzyme
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
methylation of phosphatidylethanolamine may play a role in very low density lipoprotein secretion
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
possible role of PEMT2 in the suppression of liver proliferation, and perhaps in hepatic carcinogenesis
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
activation of phosphatidylethanolamine methylation at the level of gene expression may be the mechanism by which choline-deficient rats compensate for the lack of dietary choline
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-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
enzyme form PEMT2 plays an important role in the regulation of hepatocyte cell division and as a liver tumor suppressor
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline. Loss of PEMT function may contribute to malignant transformation of hepatocytes
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
inactivation of enzyme form PEMT2 may have a role in the regulation of non-neoplastic growth of liver
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
enzyme form PEMT2 may have a role in the regulation of in vivo hepatoma and hepatocyte cell division as well as hepatocyte cell death by apoptosis
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
the transfer of a methyl group to monomethyl-N-phosphatidylcholine and dimethyl-N,N-phosphatidylcholine is catalyzed by a second enzyme
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
the first-step methylation from phosphatidylethanolamine to phosphatidylcholine is rate-limiting
-
-
?
additional information
?
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only reaction for de novo synthesis of choline in the body via methylation of phosphatidylethanolamine to form phosphatidylcholine
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-
?
additional information
?
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-
enzyme-mediated secretion of homocysteine correlates with the methyltransferase activity of the enzyme, independently of subcellular localization
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-
?
additional information
?
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-
phosphatidylethanolamine N-methyltransferase is the key enzyme for endogenous biosynthesis of phosphatidylcholine.
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-
?
additional information
?
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-
a striking gender-specific conservation of choline in female mice does not occur in male mice
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-
?
additional information
?
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-
physiological functions of phosphatidylcholine, mutational analysis, overview
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-
?
additional information
additional information
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-
Mdr2 (+/-) and Mdr2 (+/+) mice have similar S-adenosylmethionine levels at 0 and 7 days on methionine and choline deficient diet, Mdr2 (+/-) mice have significantly higher S-adenosylmethionine levels after 30 days on methionine and choline deficient diet (40.2 vs. 6.1 nmol/g).
S-adenosylhomocysteine levels are significantly lower in Mdr2 (+/-) compared to Mdr2 (+/+) mice at 0 days (33.4 vs. 41.9 nmol/g) and 7 days on methionine and choline deficient diet (16.0 vs. 42.9 nmol/g).
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?
additional information
additional information
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-
the total hepatic S-adenosylmethionine levels remain unchanged by ethanol consumption for 4 weeks
S-adenosylhomocysteine levels increase by ethanol consumption for 4 weeks. The S-adenosylmethionine:S-adenosylhomocysteine ratios are significantly lower in ethanol fed rats. Supplementation of betaine in the ethanol diet increases the hepatocellular S-adenosylmethionine:S-adenosylhomocysteine ratios to values that are statistically similar to those from rats fed the regular control diet. There is an significant inverse relationship between triglycerids and S-adenosylmethionine:S-adenosylhomocysteine ratio (r = - 0.36).
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?
additional information
additional information
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the total hepatic S-adenosylmethionine levels remain unchanged by ethanol consumption for 4 weeks
S-adenosylhomocysteine levels increase by ethanol consumption for 4 weeks. The S-adenosylmethionine:S-adenosylhomocysteine ratios are significantly lower in ethanol fed rats. Supplementation of betaine in the ethanol diet increases the hepatocellular S-adenosylmethionine:S-adenosylhomocysteine ratios to values that are statistically similar to those from rats fed the regular control diet. There is an significant inverse relationship between triglycerids and S-adenosylmethionine:S-adenosylhomocysteine ratio (r = - 0.36).
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?
