2.1.1.172: 16S rRNA (guanine1207-N2)-methyltransferase
This is an abbreviated version!
For detailed information about 16S rRNA (guanine1207-N2)-methyltransferase, go to the full flat file.
Reaction
Synonyms
16 S RNA m2G1207 methyltransferase, 16S rRNA:(guanine-N2) methyltransferase, 16S rRNA:m2G1207 MTase, 16S rRNA:m2G966 MTase, EC 2.1.1.51, EC 2.1.1.52, ribosomal RNA small subunit methyltransferase C, RNA:(guanine-N2) methyltransferase RsmC, RsmC, yjjT
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 2.1.1.172 - 16S rRNA (guanine1207-N2)-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + guanine1207 in 16S rRNA
S-adenosyl-L-homocysteine + N2-methylguanine1207 in 16S rRNA
S-adenosyl-L-homocysteine + N2-methylguanine1207 in 16S rRNA
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S-adenosyl-L-methionine + guanine1207 in 16S rRNA
S-adenosyl-L-homocysteine + N2-methylguanine1207 in 16S rRNA
because the m2G1207 methyltransferase reacts with 30S particles but barely at all with 16S RNA, it seems likely that methylation of the guanine residue occurs after the 16S RNA has associated with some ribosomal proteins
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S-adenosyl-L-methionine + guanine1207 in 16S rRNA
S-adenosyl-L-homocysteine + N2-methylguanine1207 in 16S rRNA
RsmD methyltransferase utilizes assembled ribosomal small subunit or its late assembly intermediates as a substrate. It is likely it uses the decoding cleft of the small subunit as the binding site. Nucleotide N2-methylguanine1207 is located in the helix 34 of the 16S rRNA. This functionally important helix is involved in the formation of the binding pocket for A-site bound tRNA and translocation. Despite location in the very functionally important region of the 30S subunit, N2-methylguanine1207 is not involved in the contact with tRNA. Methylation of G1207 may be necessary to freeze secondary structure in the functional conformation
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