2.1.1.176: 16S rRNA (cytosine967-C5)-methyltransferase
This is an abbreviated version!
For detailed information about 16S rRNA (cytosine967-C5)-methyltransferase, go to the full flat file.
Reaction
Synonyms
16S rRNA m5C967 methyltransferase, 16S rRNA methyltransferase, fma, fmu, Fmu/RsmB/RrmB, Fmu/RsmB/RrmB rRNA cytosine 5-methyltransferase, m5C methyltransferase Fmu, PH0851, RNA:m5C MTase, rsmB
ECTree
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Subunits
Subunits on EC 2.1.1.176 - 16S rRNA (cytosine967-C5)-methyltransferase
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monomer
two domains and one linker: an N-terminal domain formed by residues 1-145, a C-terminal domain formed by residues 185-448, and an alpha-helical linker formed by residues 146-184
additional information
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next to the S-adenosyl-L-methionine-binding site is a positively charged cleft, formed between the N- and C-terminal domains, that seems to be suitable for binding the RNA substrate. The N-terminal domains of Pyrococcus horikoshii PH0851 and Escherichia coli Fmu/RsmB/RrmB are both alpha-helical and adopt a similar topology, sequence and structure comparison, overview
additional information
next to the S-adenosyl-L-methionine-binding site is a positively charged cleft, formed between the N- and C-terminal domains, which is conserved in the archaeal PH0851 homologues and seems to be suitable for binding the RNA substrate. The N-terminal domains of Pyrococcus horikoshii PH0851 and Escherichia coli Fmu/RsmB/RrmB are both alpha-helical and adopt a similar topology, sequence and structure comparison, overview
additional information
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next to the S-adenosyl-L-methionine-binding site is a positively charged cleft, formed between the N- and C-terminal domains, which is conserved in the archaeal PH0851 homologues and seems to be suitable for binding the RNA substrate. The N-terminal domains of Pyrococcus horikoshii PH0851 and Escherichia coli Fmu/RsmB/RrmB are both alpha-helical and adopt a similar topology, sequence and structure comparison, overview
additional information
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comparison of Thermus thermophilus RsmB and RsmF protein sequences, secondary and tertiary structure, differences in substrate binding, overview
additional information
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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comparison of Thermus thermophilus RsmB and RsmF protein sequences, secondary and tertiary structure, differences in substrate binding, overview
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