2.1.1.183: 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase
This is an abbreviated version!
For detailed information about 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase, go to the full flat file.
Word Map on EC 2.1.1.183
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2.1.1.183
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pombe
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schizosaccharomyces
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tri-snrnps
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mitosis
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pre-rrnas
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nucleolar
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fission
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collagen
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ribonucleoprotein
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oncogene
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spindle
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thioredoxin-like
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pre-ribosomal
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anaphase-promoting
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metastasis-associated
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salivary
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pirin
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spliceosomal
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transketolase
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v-ha-ras
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adenoid
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cyclosome
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snrnp
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cystic
- 2.1.1.183
- pombe
-
schizosaccharomyces
-
tri-snrnps
-
mitosis
- pre-rrnas
-
nucleolar
-
fission
- collagen
- ribonucleoprotein
- oncogene
-
spindle
-
thioredoxin-like
-
pre-ribosomal
-
anaphase-promoting
-
metastasis-associated
-
salivary
- pirin
-
spliceosomal
- transketolase
-
v-ha-ras
-
adenoid
-
cyclosome
-
snrnp
-
cystic
Reaction
4 S-adenosyl-L-methionine
+
Synonyms
18S rRNA dimethylase Dim1p, DIM1, Dim1p, EC 2.1.1.48, KIDIM1, m2(6)A dimethylase, ScDim1
ECTree
2.1.1.183 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 2.1.1.183 - 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4 S-adenosyl-L-methionine + adenine1779/adenine1780 in 18S rRNA
4 S-adenosyl-L-homocysteine + N6-dimethyladenine1779/N6-dimethyladenine1780 in 18S rRNA
Dim1p is required for pre-ribosomal RNA processing
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?
4 S-adenosyl-L-methionine + adenine1779/adenine1780 in 18S rRNA
4 S-adenosyl-L-homocysteine + N6-dimethyladenosine1779/N6-dimethyladenine1780 in 18S rRNA
isolation of mutations that uncouple the enzymatic function of Dim1p in methylation from its involvement in prerRNA processing
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-
?
4 S-adenosyl-L-methionine + adenine1779/adenine1780 in 18S rRNA
4 S-adenosyl-L-homocysteine + N6-dimethyladenosine1779/N6-dimethyladenosine1780 in 18S rRNA
neither the bacterial nor the archaeal ortholog could complement for the eukaryotic Dim1. This might be related to the secondary, non-methyltransferase function that Dim1 is known to play in eukaryotic ribosomal maturation
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-
?
