2.1.1.186: 23S rRNA (cytidine2498-2'-O)-methyltransferase
This is an abbreviated version!
For detailed information about 23S rRNA (cytidine2498-2'-O)-methyltransferase, go to the full flat file.
Reaction
Synonyms
2O-ribose methyltransferase, Cm2498, RlmM, rRNA large subunit methyltransferase M, ygdE
ECTree
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General Information
General Information on EC 2.1.1.186 - 23S rRNA (cytidine2498-2'-O)-methyltransferase
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evolution
malfunction
C2498 methylation and the putative second methylation observed in the wild-type (YgdE+) strain are completely absent in the DygdE strain. Inactivation of the ygdE gene leads to loss of methylation at nucleotide C2498. The loss of ygdE function causes a slight reduction in bacterial fitness
physiological function
the catalytic domain of RlmM is closely related to YiiB, TlyA and fibrillarins, with the second K of the catalytic tetrad KDKE shifted by two residues at the C-terminal end of a beta strand compared with most 2'O MTases
evolution
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the catalytic domain of RlmM is closely related to YiiB, TlyA and fibrillarins, with the second K of the catalytic tetrad KDKE shifted by two residues at the C-terminal end of a beta strand compared with most 2'O MTases
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RlmM catalyzes the S-adenosyl methionine-dependent 20O methylation of C2498 in 23S ribosomal RNA of Escherichia coli
physiological function
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RlmM catalyzes the S-adenosyl methionine-dependent 20O methylation of C2498 in 23S ribosomal RNA of Escherichia coli
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