2.1.1.187: 23S rRNA (guanine745-N1)-methyltransferase

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For detailed information about 23S rRNA (guanine745-N1)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.187

2.1.1.187

rrnas

macrolide

methyltransferases

tylosin

fradiae

pneumoniae

stem-loops

Reaction

Synonyms

23S rRNA m1G745 methyltransferase, 23S rRNA:m1G745 methyltransferase, ribosomal RNA(m1G)-methylase, RlmA, RlmA(I), RlmAI, RlmAI methyltransferase, rRNA large subunit methyltransferase I, rRNA(m1G)methylase, YebH

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.187 23S rRNA (guanine745-N1)-methyltransferase

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Results	in table
2191	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
1	Crystallization (Commentary)
4	General Information
1	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
18	Organism
11	pH Optimum
7	Purification (Commentary)
1	Reaction
18	Reference
17	Substrates and Products (Substrate)
1	Subunits
32	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]

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Reference on EC 2.1.1.187 - 23S rRNA (guanine745-N1)-methyltransferase

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440039

Isaksson, L.A.

Partial purification of ribosomal RNA(m1G)- and rRNA(m2G)-methylases from Escherichia coli and demonstration of some proteins affecting their apparent activity

Biochim. Biophys. Acta

312

122-133

1973

Escherichia coli (P36999)

4580201

441500

Hansen, L.H.; Kirpekar, F.; Douthwaite, S.

Recognition of nucleotide G745 in 23 S ribosomal RNA by the RrmA methyltransferase

J. Mol. Biol.

310

1001-1010

2001

Escherichia coli (P36999)

11501991

441501

Liu, M.; Douthwaite, S.

Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes gram-negative from gram-positive bacteria

Mol. Microbiol.

195-204

2002

Klebsiella aerogenes, Dickeya chrysanthemi, Proteus mirabilis, Pseudomonas putida, Pseudomonas fluorescens, Shewanella putrefaciens, Pseudomonas stutzeri (A4VMZ0), Azotobacter vinelandii (C1DSW3), Escherichia coli (P36999), Escherichia coli, Pseudomonas syringae (Q48F48), Acinetobacter sp. (Q9AEP4), Acinetobacter sp. ADP1 (Q9AEP4)

11967079

441502

Bujnicki, J.M.; Blumenthal, R.M.; Rychlewski, L.

Sequence analysis and structure prediction of 23S rRNA:m1G methyltransferases reveals a conserved core augmented with a putative Zn-binding domain in the N-terminus and family-specific elaborations in the C-terminus

J. Mol. Microbiol. Biotechnol.

93-99

2002

Escherichia coli (P36999)

11763974

660369

Das, K.; Acton, T.; Chiang, Y.; Shih, L.; Arnold, E.; Montelione, G.T.

Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site

Proc. Natl. Acad. Sci. USA

101

4041-4046

2004

Escherichia coli (P36999), Escherichia coli

14999102

660492

Liu, M.; Novotny, G.W.; Douthwaite, S.

Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase

RNA

1713-1720

2004

Acinetobacter sp. (Q9AEP4)

15388872

704259

Gustafsson, C.; Persson, B.C.

Identification of the rrmA gene encoding the 23S rRNA m1G745 methyltransferase in Escherichia coli and characterization of an m1G745-deficient mutant

J. Bacteriol.

180

359-365

1998

Escherichia coli (P36999), Escherichia coli

9440525