2.1.1.188: 23S rRNA (guanine748-N1)-methyltransferase
This is an abbreviated version!
For detailed information about 23S rRNA (guanine748-N1)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.188
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2.1.1.188
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rrnas
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macrolide
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fradiae
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methyltransferases
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stem-loops
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dimethyltransferase
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streptogramin
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footprint
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lincosamide
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exit
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telithromycin
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16-membered
- 2.1.1.188
- rrnas
-
macrolide
- fradiae
- methyltransferases
-
stem-loops
-
dimethyltransferase
-
streptogramin
-
footprint
-
lincosamide
-
exit
- telithromycin
-
16-membered
Reaction
Synonyms
methyltransferase RlmAII, RlmA II, RlmA(II), RlmAII, rRNA large subunit methyltransferase II, TlrB, tylosin resistance methyltransferase RlmA(II), tylosin-resistance methyltransferase RlmA(II)
ECTree
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Reference
Reference on EC 2.1.1.188 - 23S rRNA (guanine748-N1)-methyltransferase
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Liu, M.; Douthwaite, S.
Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes gram-negative from gram-positive bacteria
Mol. Microbiol.
44
195-204
2002
Priestia megaterium, Bacillus subtilis, Corynebacterium glutamicum, Streptococcus pneumoniae, Enterococcus faecalis, Lactiplantibacillus plantarum, Lactococcus lactis, Streptococcus thermophilus, Micromonospora griseorubida, Rhodococcus corynebacterioides, Streptomyces fradiae (Q9S1M6), Streptomyces fradiae
Lebars, I.; Yoshizawa, S.; Stenholm, A.R.; Guittet, E.; Douthwaite, S.; Fourmy, D.
Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII
EMBO J.
22
183-192
2003
Streptococcus pneumoniae
Douthwaite, S.; Crain, P.F.; Liu, M.; Poehlsgaard, J.
The tylosin-resistance methyltransferase RlmAII (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748
J. Mol. Biol.
337
1073-1077
2004
Streptomyces fradiae (Q9S1M6), Streptomyces fradiae
Douthwaite, S.; Jakobsen, L.; Yoshizawa, S.; Fourmy, D.
Interaction of the tylosin-resistance methyltransferase RlmA II at its rRNA target differs from the orthologue RlmA I
J. Mol. Biol.
378
969-975
2008
Streptococcus pneumoniae
Lebars, I.; Husson, C.; Yoshizawa, S.; Douthwaite, S.; Fourmy, D.
Recognition elements in rRNA for the tylosin resistance methyltransferase RlmA(II)
J. Mol. Biol.
372
525-534
2007
Streptococcus pneumoniae
Liu, M.; Kirpekar, F.; van Wezel, G.P.; Douthwaite, S.
The tylosin resistance gene tlrB of Streptomyces fradiae encodes a methyltransferase that targets G748 in 23S rRNA
Mol. Microbiol.
37
811-820
2000
Streptomyces fradiae (Q9S1M6)
Takaya, A.; Sato, Y.; Shoji, T.; Yamamoto, T.
Methylation of 23S rRNA nucleotide G748 by RlmAII methyltransferase renders Streptococcus pneumoniae telithromycin susceptible
Antimicrob. Agents Chemother.
57
3789-3796
2013
Streptococcus pneumoniae, Streptococcus pneumoniae S1
Shoji, T.; Takaya, A.; Sato, Y.; Kimura, S.; Suzuki, T.; Yamamoto, T.
RlmCD-mediated U747 methylation promotes efficient G748 methylation by methyltransferase RlmAII in 23S rRNA in Streptococcus pneumoniae; interplay between two rRNA methylations responsible for telithromycin susceptibility
Nucleic Acids Res.
43
8964-8972
2015
Streptococcus pneumoniae, Streptococcus pneumoniae S1
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