2.1.1.190: 23S rRNA (uracil1939-C5)-methyltransferase

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For detailed information about 23S rRNA (uracil1939-C5)-methyltransferase, go to the full flat file.

Reaction

Synonyms

m5U methyltransferase, Mcap0476, RlmCD, RlmD, RlmFO, RNA m5U methyltransferase, RNA uridine methyltransferase A, RumA, SP 1029, SP_1029, YefA, YgcA

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.190 23S rRNA (uracil1939-C5)-methyltransferase

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Results	in table
16541	AA Sequence
4	Cloned(Commentary)
4	Cofactor
4	Crystallization (Commentary)
3	General Information
4	KM Value [mM]
4	Metals/Ions
9	Natural Substrates/ Products (Substrates)
14	Organism
1	pH Optimum
12	Protein Variants
3	Purification (Commentary)
1	Reaction
13	Reference
16	Substrates and Products (Substrate)
26	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
4	Turnover Number [1/s]

General Information

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General Information on EC 2.1.1.190 - 23S rRNA (uracil1939-C5)-methyltransferase

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evolution

Bacillus subtilis

YefA is a COG2265 member. During evolution, COG2265 enzymes have undergone a series of changes in target specificity and YefA is closer to an archetypical m5U methyltransferase. A functional shift has occurred during the evolution of the Bacillus subtilis YefA and YfjO methyltransferases.To reflect its dual specificity, YefA is renamed RlmCD

720592

malfunction

Escherichia coli

P55135

strains lacking the RumA methylase are gradually out-competed by wild type strains in growth competition experiments, suggesting that the m5U methylation improves ribosome performance. Base substitutions at U1939 in 23S rRNA have little effect on growth or the fidelity of translation, but alter the sensitivity of the ribosomes to the antibiotics fusidic acid and capreomycin

702095

physiological function

Escherichia coli

RlmD is the archetypical enzyme that is specific for m5U1939 in 23S rRNA

721031