2.1.1.193: 16S rRNA (uracil1498-N3)-methyltransferase

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For detailed information about 16S rRNA (uracil1498-N3)-methyltransferase, go to the full flat file.

Reaction

Synonyms

16S rRNA methyltransferase, DUF558 protein, m3U1498 specific methyltransferase, PA0419, RsmE, Rv2372c, YggJ

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.193 16S rRNA (uracil1498-N3)-methyltransferase

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Results	in table
1	Activating Compound
41978	AA Sequence
2	Cloned(Commentary)
1	Cofactor
2	Crystallization (Commentary)
4	General Information
1	Inhibitors
3	KM Value [mM]
3	Metals/Ions
2	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
5	Organism
18	PDB ID
3	pH Optimum
1	Protein Variants
2	Purification (Commentary)
2	Reaction
5	Reference
8	Substrates and Products (Substrate)
5	Subunits
11	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Turnover Number [1/s]

Subunits

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Subunits on EC 2.1.1.193 - 16S rRNA (uracil1498-N3)-methyltransferase

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x * 29000, SDS-PAGE

dimer

homodimer

the crystal structure in monomer shows that RsmE consists of two distinct but structurally related domains: the pseudouridine synthases and archaeosine-specific transglycosylasess-like RNA recognition and binding domain, PUA, and the conserved MTase domain with a deep trefoil knot

720262

additional information

Escherichia coli

P0AGL7

the methylation process is required by collaboration of both subunits, and dimerization is functionally critical for catalysis. Molecular replacement of crystal structure, PDB ID 1VHY. Structural comparisons of N-terminal and C-terminal domains of RsmE with related proteins, overview

720262