2.1.1.202: multisite-specific tRNA:(cytosine-C5)-methyltransferase
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For detailed information about multisite-specific tRNA:(cytosine-C5)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.202
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2.1.1.202
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methyltransferases
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mtases
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methylome
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williams-beuren
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anticodon
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transcriptome-wide
- 2.1.1.202
- methyltransferases
- mtases
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methylome
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williams-beuren
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anticodon
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transcriptome-wide
Reaction
Synonyms
5-methylcytosine RNA methyltransferase, broad-spectrum methyltransferase, cytosine-5 RNA methyltransferase, EC 2.1.1.29, HNSun6, M5C RNA methyltransferase, MJ0026, multisite-specific tRNA:m5C-methyltransferase, Ncl1p, NOP2/Sun RNA methyltransferase 2, NSUN2, NSUN6, PhNSUN6, RNA (cytosine-5)-methyltransferase, RNA:m5C methyltransferase, RNA:m5C MTase, TRDMT1, TRM4, TRM4A, TRM4B, Trm4p, tRNA (cytosine72-C5)-methyltransferase, tRNA-specific methyltransferase 4B, tRNA:m5C-methyltransferase, tRNA:m5C72 MTase
ECTree
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Source Tissue
Source Tissue on EC 2.1.1.202 - multisite-specific tRNA:(cytosine-C5)-methyltransferase
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reduction of upper-layer neurons in the Nsun2 -/- cortex, mouse brain cortex at E18.5 showing the location of the indicated markers
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slightly increasing trend of m5C modification in mRNA from 3- to 15-day-old whole seedlings undergoing vegetative, floral transitional, and reproductive stages
additional information
NSUN2 is expressed in stem and progenitor cells during human brain development
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transcriptome-wide profiling of m5C RNA in Arabidopsis thaliana is made by applying m5C RNA immunoprecipitation followed by a deepsequencing approach (m5C-RIP-seq). LC-MS/MS and dot blot analyses reveal a dynamic pattern of m5C mRNA modification in various tissues and at different developmental stages. m5C-RIP-seq analysis identified 6045m5C peaks in 4465 expressed genes in young seedlings. m5C is enriched in coding sequences with two peaks located immediately after start codons and before stop codons, and is associated with mRNAs with low translation activity. Spatial change in m5C levels in different tissues
additional information
NSUN2 is expressed in early neuroepithelial progenitors of the developing human brain, and its expression is gradually reduced during differentiation of human neuroepithelial stem (NES) cells in vitro. Nucleolar expression of NSUN2 overlaps with SOX1, a marker for early neuroepithelial progenitors in the neural tube. NSUN2 is expressed in early neuroectodermal cells that are capable of differentiating into various region-specific neuronal and glial cell types. NSUN2 co-localized with Nestin and SOX1 in cultured NES cells, both lines Sai1 and AF22 express high levels of the NES cell markers Nestin and SOX2 but very low levels of the neural differentiation marker betaIII-tubulin (TUBB3)
additional information
NSUN2 is overexpressed in a number of human cancers
additional information
nucleolar expression of NSUN2 overlaps with SOX1, a marker for early neuroepithelial progenitors in the neural tube. NSUN2 is expressed in early neuroectodermal cells that are capable of differentiating into various region-specific neuronal and glial cell types
additional information
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tRNAHis m5C levels are unusually responsive to yeast growth conditions