2.1.1.203: tRNA (cytosine34-C5)-methyltransferase
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For detailed information about tRNA (cytosine34-C5)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.203
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2.1.1.203
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5-methylcytosine
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anticodon
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homocysteine
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wobble
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ualcan
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5-formylcytosine
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biallelic
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omnibus
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shrinkage
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hyperhomocysteinemia
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encephalomyopathy
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nsun2-mediated
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epitranscriptome
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early-onset
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medicine
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pharmacology
- 2.1.1.203
- 5-methylcytosine
-
anticodon
- homocysteine
-
wobble
-
ualcan
- 5-formylcytosine
-
biallelic
-
omnibus
-
shrinkage
-
hyperhomocysteinemia
- encephalomyopathy
-
nsun2-mediated
-
epitranscriptome
-
early-onset
- medicine
- pharmacology
Reaction
Synonyms
5-methylcytosine RNA methyltransferase, cytosine-5 RNA methyltransferase, cytosine-5 tRNA methyltransferase, DnmA, EC 2.1.1.29, hTrm4, M5C RNA methyltransferase, NOP2/Sun domain family member 2, NSUN2, NSUN3, NSUN3 methylase, PMT1, RCMT, RNA:m5C methyltransferase, SAKI, substrate of AIM-1/Aurora kinase B
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Application on EC 2.1.1.203 - tRNA (cytosine34-C5)-methyltransferase
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medicine
this methyltransferase is a novel downstream Myctarget which mediates Myc-induced cell proliferation and growth. Therefore, the characterization of hTrm4 substrate specificity can be essential since this enzyme is a potential target for cancer therapies
pharmacology
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enzymes NSUN2 and METTL1 are implicated in 5-fluorouracil sensitivity in HeLa cells. Interfering with methylation of tRNAs might provide a promising rationale to improve 5-fluorouracil chemotherapy of cancer