2.1.1.203: tRNA (cytosine34-C5)-methyltransferase

This is an abbreviated version!
For detailed information about tRNA (cytosine34-C5)-methyltransferase, go to the full flat file.

Reaction

Synonyms

5-methylcytosine RNA methyltransferase, cytosine-5 RNA methyltransferase, cytosine-5 tRNA methyltransferase, DnmA, EC 2.1.1.29, hTrm4, M5C RNA methyltransferase, NOP2/Sun domain family member 2, NSUN2, NSUN3, NSUN3 methylase, PMT1, RCMT, RNA:m5C methyltransferase, SAKI, substrate of AIM-1/Aurora kinase B

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.203 tRNA (cytosine34-C5)-methyltransferase

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Results	in table
2	Activating Compound
1744	AA Sequence
2	Application
5	Cloned(Commentary)
8	Cofactor
17	Disease/ Diagnostics
1	Expression
29	General Information
9	Localization
1	Metals/Ions
1	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
17	Organism
1	Pathway
2	pH Optimum
1	Posttranslational Modification
12	Protein Variants
1	Purification (Commentary)
2	Reaction
15	Reference
13	Source Tissue
22	Substrates and Products (Substrate)
1	Subunits
29	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.1.1.203 - tRNA (cytosine34-C5)-methyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-methionine + cytidine34 in mitochondrial tRNA

S-adenosyl-L-homocysteine + 5-methylcytidine34 in mitochondrial tRNA

Homo sapiens

Q9H649

-

757733

-

-

?

S-adenosyl-L-methionine + cytosine34 in mitochondrial tRNAMet precursor

S-adenosyl-L-homocysteine + 5-methylcytosine34 in mitochondrial tRNAMet precursor

2 entries

S-adenosyl-L-methionine + cytosine34 in mitochondrial tRNAMet(AUA) precursor

S-adenosyl-L-homocysteine + 5-methylcytosine34 in mitochondrial tRNAMet(AUA) precursor

Homo sapiens

Q9H649

-

757733

-

-

?

S-adenosyl-L-methionine + cytosine34 in tRNA

S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor

Homo sapiens

Q08J23

specific modification of cytosine34 in the intron-containing yeast pre-tRNALeu(CAA)

710135

-

-

?

S-adenosyl-L-methionine + cytosine34 in tRNA precursor

S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor

4 entries

S-adenosyl-L-methionine + cytosine34 in tRNALeu(CAG) precursor

S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNALeu(CAG) precursor

Homo sapiens

Q08J23

-

758103

-

-

?

S-adenosyl-L-methionine + microRNA 125b

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

the tRNA methyltransferase NSun2 methylates primary (pri-miR-125b), precursor (pre-miR-125b), and mature microRNA 125b (miR-125b) in vitro and in vivo

736798

-

-

?

additional information

?

-

3 entries

S-adenosyl-L-methionine + cytosine34 in mitochondrial tRNAMet precursor

S-adenosyl-L-homocysteine + 5-methylcytosine34 in mitochondrial tRNAMet precursor

Homo sapiens

Q9H649

-

756866

-

-

?

S-adenosyl-L-methionine + cytosine34 in mitochondrial tRNAMet precursor

S-adenosyl-L-homocysteine + 5-methylcytosine34 in mitochondrial tRNAMet precursor

Saccharomyces cerevisiae

Q9H649

-

756866

-

-

?

S-adenosyl-L-methionine + cytosine34 in tRNA precursor

S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor

Drosophila melanogaster

Q9W4M9

-

756399

-

-

?

S-adenosyl-L-methionine + cytosine34 in tRNA precursor

S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor

Homo sapiens

-

-

718539

-

-

?

S-adenosyl-L-methionine + cytosine34 in tRNA precursor

S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor

Homo sapiens

Q08J23

-

758103

-

-

?

S-adenosyl-L-methionine + cytosine34 in tRNA precursor

S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor

Mus musculus

-

-

718539

-

-

?

additional information

?

-

Homo sapiens

Q08J23

levels of m5C changes site-specifically and dynamically in response to oxidative stress. All individual m5C sites showing significantly different methylation levels in NSUN2-rescued cells after 2 or 4 hours of stress. Methylation levels within the same tRNA molecule are independent from each other

758103

-

-

-

additional information

?

-

Mammalia

-

the Nsun2 fabricate 5-methylcytosine (m5C) in RNA molecules utilizing a dual-cysteine catalytic mechanism

735680

-

-

?

additional information

?

-

Mus musculus

-

NSun2 catalyzes the formation of cytosine-5 methylation in several tRNAs in vivo in tissues, including skin, liver, and testis

734682

-

-

?