2.1.1.203: tRNA (cytosine34-C5)-methyltransferase
This is an abbreviated version!
For detailed information about tRNA (cytosine34-C5)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.203
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2.1.1.203
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5-methylcytosine
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anticodon
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homocysteine
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wobble
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ualcan
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5-formylcytosine
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biallelic
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omnibus
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shrinkage
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hyperhomocysteinemia
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encephalomyopathy
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nsun2-mediated
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epitranscriptome
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early-onset
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medicine
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pharmacology
- 2.1.1.203
- 5-methylcytosine
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anticodon
- homocysteine
-
wobble
-
ualcan
- 5-formylcytosine
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biallelic
-
omnibus
-
shrinkage
-
hyperhomocysteinemia
- encephalomyopathy
-
nsun2-mediated
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epitranscriptome
-
early-onset
- medicine
- pharmacology
Reaction
Synonyms
5-methylcytosine RNA methyltransferase, cytosine-5 RNA methyltransferase, cytosine-5 tRNA methyltransferase, DnmA, EC 2.1.1.29, hTrm4, M5C RNA methyltransferase, NOP2/Sun domain family member 2, NSUN2, NSUN3, NSUN3 methylase, PMT1, RCMT, RNA:m5C methyltransferase, SAKI, substrate of AIM-1/Aurora kinase B
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Substrates Products
Substrates Products on EC 2.1.1.203 - tRNA (cytosine34-C5)-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + cytidine34 in mitochondrial tRNA
S-adenosyl-L-homocysteine + 5-methylcytidine34 in mitochondrial tRNA
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S-adenosyl-L-methionine + cytosine34 in mitochondrial tRNAMet precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in mitochondrial tRNAMet precursor
S-adenosyl-L-methionine + cytosine34 in mitochondrial tRNAMet(AUA) precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in mitochondrial tRNAMet(AUA) precursor
S-adenosyl-L-methionine + cytosine34 in tRNA
S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor
specific modification of cytosine34 in the intron-containing yeast pre-tRNALeu(CAA)
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S-adenosyl-L-methionine + cytosine34 in tRNA precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor
S-adenosyl-L-methionine + cytosine34 in tRNALeu(CAG) precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNALeu(CAG) precursor
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S-adenosyl-L-methionine + cytosine34 in tRNAPro
S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNAPro
S-adenosyl-L-methionine + microRNA 125b
S-adenosyl-L-homocysteine + ?
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the tRNA methyltransferase NSun2 methylates primary (pri-miR-125b), precursor (pre-miR-125b), and mature microRNA 125b (miR-125b) in vitro and in vivo
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S-adenosyl-L-homocysteine + 5-methylcytosine34 in mitochondrial tRNAMet precursor
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S-adenosyl-L-methionine + cytosine34 in mitochondrial tRNAMet precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in mitochondrial tRNAMet precursor
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S-adenosyl-L-homocysteine + 5-methylcytosine34 in mitochondrial tRNAMet(AUA) precursor
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S-adenosyl-L-methionine + cytosine34 in mitochondrial tRNAMet(AUA) precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in mitochondrial tRNAMet(AUA) precursor
secondary structure of human mt-tRNAMet with modifications f5C and pseudouridine. The anticodon pairs with AUG and AUA codons, overview
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S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor
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S-adenosyl-L-methionine + cytosine34 in tRNA precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor
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S-adenosyl-L-methionine + cytosine34 in tRNA precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor
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S-adenosyl-L-methionine + cytosine34 in tRNA precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor
specific modification of cytosine34 in the intron-containing yeast pre-tRNALeu(CAA). The hTrm4 MTase has a much narrower specificity against the yeast substrates than its yeast orthologue. The human enzyme is not able to form 5-methylcytosine34 at positions 48 and 49 of human and yeast tRNA precursors. Intron in the human pre-tRNALeu(CAA) is indispensable for the C5-methylation of cytosine in the first position of the anticodon. The modification of C34 depends on the nucleotide sequence surrounding the position to be modified and on the structure of intron-containing prolongated anticodon stem
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S-adenosyl-L-methionine + cytosine34 in tRNA precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor
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S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNAPro
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S-adenosyl-L-methionine + cytosine34 in tRNAPro
S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNAPro
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S-adenosyl-L-methionine + cytosine34 in tRNAPro
S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNAPro
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levels of m5C changes site-specifically and dynamically in response to oxidative stress. All individual m5C sites showing significantly different methylation levels in NSUN2-rescued cells after 2 or 4 hours of stress. Methylation levels within the same tRNA molecule are independent from each other
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additional information
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NSUN2-methylated tRNA sites are located in the anticodon loop (C34) and the VL (C46, C47), number of m5C per tRNA in all tRNAs or tRNA leucine, mass spectrometry, overview
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additional information
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the Nsun2 fabricate 5-methylcytosine (m5C) in RNA molecules utilizing a dual-cysteine catalytic mechanism
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additional information
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the enzyme forms covalent complexes with previously methylated RNA requiring S-adenosyl-L-homocysteine, the removal of this metabolite results in the disassembly of preexisting complexes
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additional information
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NSun2 catalyzes the formation of cytosine-5 methylation in several tRNAs in vivo in tissues, including skin, liver, and testis
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additional information
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the presence of a stable anticodon stem is found to be essential for formation of m5C34 of mt-tRNAMet by NSUN3
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