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2.1.1.204: tRNA (cytosine38-C5)-methyltransferase

This is an abbreviated version!
For detailed information about tRNA (cytosine38-C5)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.204

Reaction

S-adenosyl-L-methionine
+
cytosine38 in tRNA
=
S-adenosyl-L-homocysteine
+
5-methylcytosine38 in tRNA

Synonyms

(cytosine-5) RNA methyltransferase, cytosine-5 tRNA methyltransferase, dDnmt2, DNA methyltransferase 2, DnmA, Dnmt2, DNMT2 methyltransferase, EC 2.1.1.29, hDNMT2, Pf-DNMT2, PMT1, pombe methyltransferase 1, RCMT, RNA methyltransferase, spDnmt2, transfer RNA aspartic acid methyltransferase 1, TRDMT1, tRNA aspartic acid methyltransferase 1, tRNA-aspartic acid methyltransferase 1

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.204 tRNA (cytosine38-C5)-methyltransferase

Disease

Disease on EC 2.1.1.204 - tRNA (cytosine38-C5)-methyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma of Lung
RNA methyltransferase METTL3 induces intrinsic resistance to gefitinib by combining with MET to regulate PI3K/AKT pathway in lung adenocarcinoma.
Bone Resorption
Circ_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation.
Breast Neoplasms
BCDIN3D RNA methyltransferase stimulates Aldolase C expression and glycolysis through let-7 microRNA in breast cancer cells.
Elevated expression of RNA methyltransferase BCDIN3D predicts poor prognosis in breast cancer.
Human BCDIN3D monomethylates cytoplasmic histidine transfer RNA.
Carcinogenesis
METTL14 facilitates global genome repair and suppresses skin tumorigenesis.
Carcinoma
RNA methyltransferase NSUN2 promotes hypopharyngeal squamous cell carcinoma proliferation and migration by enhancing TEAD1 expression in an m5C-dependent manner.
Carcinoma, Ehrlich Tumor
Recognition of the ribosomal RNA structures by purified nucleolar RNA methyltransferase.
Carcinoma, Hepatocellular
RNA methyltransferase NSUN2 promotes growth of hepatocellular carcinoma cells by regulating fizzy-related-1 in vitro and in vivo.
The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1(RNMTL1) gene, a newly discovered 17p13.3 gene.
The Role of RNA Methyltransferase METTL3 in Hepatocellular Carcinoma: Results and Perspectives.
[METTL14 as a predictor of postoperative survival outcomes of patients with hepatocellular carcinoma].
Carcinoma, Non-Small-Cell Lung
The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer.
Cystic Fibrosis
Identification of Aminoglycoside-resistant Pseudomonas aeruginosa producing RmtG 16S ribosomal RNA methyltransferase in a cystic fibrosis patient.
Gastrointestinal Neoplasms
Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer.
Glioma
Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program.
Hearing Loss
Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness.
Infections
Temperature-dependent survival of Turnip crinkle virus-infected arabidopsis plants relies on an RNA silencing-based defense that requires dcl2, AGO2, and HEN1.
Intellectual Disability
Mutation in NSUN2, which encodes an RNA methyltransferase, causes autosomal-recessive intellectual disability.
Lung Neoplasms
The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer.
Neoplasm Metastasis
NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation.
Neoplasms
METTL3 expression is associated with glycolysis metabolism and sensitivity to glycolytic stress in hepatocellular carcinoma.
METTL3?mediated m6A modification of Bcl?2 mRNA promotes non?small cell lung cancer progression.
NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation.
Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer.
Recognition of the ribosomal RNA structures by purified nucleolar RNA methyltransferase.
Regulation of telomere homeostasis and genomic stability in cancer by N 6-adenosine methylation (m6A).
RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Kip2 by an m5C-dependent manner.
RNA methyltransferase NSUN2 promotes hypopharyngeal squamous cell carcinoma proliferation and migration by enhancing TEAD1 expression in an m5C-dependent manner.
The Critical Role of RNA m6A Methylation in Cancer.
The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors.
The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer.
Ubiquitination-mediated degradation of TRDMT1 regulates homologous recombination and therapeutic response.
Virion-associated and cellular RNA methylase activity in normal and neoplastic mammary tissue from mammary tumor virus-infected and -uninfected mice.
Osteoarthritis
METTL3 promotes experimental osteoarthritis development by regulating inflammatory response and apoptosis in chondrocyte.
Pancreatic Neoplasms
The RNA methyltransferase NSUN6 suppresses pancreatic cancer development by regulating cell proliferation.
Spinal Dysraphism
An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).
Squamous Cell Carcinoma of Head and Neck
RNA methyltransferase NSUN2 promotes hypopharyngeal squamous cell carcinoma proliferation and migration by enhancing TEAD1 expression in an m5C-dependent manner.
Stomach Neoplasms
RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Kip2 by an m5C-dependent manner.
Tuberculosis
A Novel Motif for S-Adenosyl-l-methionine Binding by the Ribosomal RNA Methyltransferase TlyA from Mycobacterium tuberculosis.
Wilms Tumor
mTORC1 promotes cell growth via m6A-dependent mRNA degradation.
mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis.