2.1.1.209: 23S rRNA (guanine2535-N1)-methyltransferase
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For detailed information about 23S rRNA (guanine2535-N1)-methyltransferase, go to the full flat file.
Reaction
Synonyms
AviRa
ECTree
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Systematic Name
Systematic Name on EC 2.1.1.209 - 23S rRNA (guanine2535-N1)-methyltransferase
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S-adenosyl-L-methionine:23S rRNA (guanine2535-N1)-methyltransferase
Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (guanine2535-N1)-methyltransferase and EC 2.1.1.208 [23S rRNA (uridine2479-2-O)-methyltransferase], whose actions confer avilamycin resistance to the RNA.