2.1.1.212: 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase
This is an abbreviated version!
For detailed information about 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase, go to the full flat file.
Reaction
Synonyms
2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase/isoflavone 4'-O-methyltransferase, 2-hydroxyisoflavanone 4'-O-methyltransferase, HI4'OMT, HI4'OMT/HM3OMT, HI4OMT, HMM1, More, MtIOMT5, S-adenosyl-L-methionine: 2-hydroxyisoflavanone 4'-O-methyltransferase, SAM: 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase, SAM:2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase
ECTree
2.1.1.212 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.1.1.212 - 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 2,4',7-trihydroxyisoflavanone
S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
-
-
-
?
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
-
-
-
?
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
-
-
?
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
the enzyme is involved in formononetin biosynthesis
-
-
?
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
the enzyme is involved in formononetin biosynthesis in legumes
-
-
?
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
HI4'OMT shows efficiencies (relative Vmax/Km) for the 4'-O-methylation of 2,7,4'-trihydroxyisoflavanone 20 times higher than for the 3-O-methylation of (+)-6a-hydroxymaackiain, respectively
-
-
?
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
-
-
?
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
the enzyme is involved in formononetin biosynthesis
-
-
?
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
-
-
?
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
the enzyme is involved in formononetin biosynthesis in legumes
-
-
?
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
-
-
?
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
the bifunctional enzyme also catalyzes the 3-O-methylation of (+)-6a-hydroxymaackiain, with slightly lower catalytic efficiency
-
-
?
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
-
-
-
?
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
in pea, HMM1 is the equivalent of the HI4'OMT found in other legumes and is involved in formononetin biosynthesis
-
-
?
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
HMM1 shows efficiencies (relative Vmax/Km) for the 4'-O-methylation of 2,7,4'-trihydroxyisoflavanone 4 times higher than for the 3-O-methylation of (+)-6a-hydroxymaackiain
-
-
?
additional information
?
-
-
the bifunctionally enzyme typically converts daidzein to formononetin or genistein to biochanin A (reaction of EC 2.1.1.46)
-
-
-
additional information
?
-
low activity with dihydrodaidzein. 4'-Methoxy, 7-methoxy, and 4',7-dimethoxy products are formed in the reaction with dihydrodaidzein. No activity with: 6,7,4'-trihydroxyisoflavone, 6,7'-dihydroxy,4'-methoxyisoflavone, 7,3',4'-trihydroxyisoflavone, daidzein, genistein, glycitein, coumestrol, apigenin, 7,4'-dihydroxyflavone and myricetin
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-
?
