2.1.1.215: tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase

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For detailed information about tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase, go to the full flat file.

Reaction

4 S-adenosyl-L-methionine +

= 4 S-adenosyl-L-homocysteine +

N2-dimethylguanine26/N2-dimethylguanine27 in tRNA

Synonyms

EC 2.1.1.32, multisite-specific tRNA methyltransferase, Trm1, Trm1[tRNA (m2(2)G26) methyltransferase], tRNA (m2(2)G26) methyltransferase, tRNA (N2,N2-guanine)-dimethyltransferase, tRNA:m22G26-methyltransferase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.215 tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase

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Results	in table
88	AA Sequence
4	Cloned(Commentary)
2	Cofactor
1	General Information
1	IC50 Value
1	Inhibitors
15	KM Value [mM]
1	Metals/Ions
7	Natural Substrates/ Products (Substrates)
5	Organism
2	pH Optimum
22	Protein Variants
2	Purification (Commentary)
2	Reaction
5	Reference
23	Substrates and Products (Substrate)
1	Subunits
11	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

General Information

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General Information on EC 2.1.1.215 - tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase

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evolution

Aquifex aeolicus

archaeal and eukaryotic tRNA (N2,N2-guanine)-dimethyltransferase, Trm1, produces N2,N2-dimethylguanine at position 26 in tRNA. In contrast, Trm1 from Aquifex aeolicus, a hyper-thermophilic eubacterium, modifies G27 as well as G26. The overall structure of Aquifex aeolicus Trm1 is similar to that of archaeal Trm1, although there is a zinc-cysteine cluster in the C-terminal domain of Aquifex aeolicus Trm1

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