2.1.1.216: tRNA (guanine26-N2)-dimethyltransferase
This is an abbreviated version!
For detailed information about tRNA (guanine26-N2)-dimethyltransferase, go to the full flat file.
Reaction
2 S-adenosyl-L-methionine + = 2 S-adenosyl-L-homocysteine +
Synonyms
EC 2.1.1.32, Ta0997, transfer RNA methyltransferase, Trm1, Trm1 methyltransferase, Trm1p, tRNA (guanine(26)-N(2))-dimethyltransferase, tRNA (m22G26)dimethyltransferase, tRNA(guanine-26,N2-N2) methyltransferase, tRNA(guanine26,N2,N2)-dimethyltransferase, tRNA(m22G26)dimethyltransferase, ZC376.5
ECTree
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Activating Compound
Activating Compound on EC 2.1.1.216 - tRNA (guanine26-N2)-dimethyltransferase
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Rapamycin
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a decrease in tRNA synthesis by treatment with rapamycin leads to increased N2,N2-dimethyl G26 modification
additional information
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RNA polymerase III mutations associated with hypomyelinating leukodystrophy decrease tRNA transcription, increase of N2,N2-dimethyl G26 modification efficiency and reverse antisuppression
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