2.1.1.220: tRNA (adenine58-N1)-methyltransferase

This is an abbreviated version!
For detailed information about tRNA (adenine58-N1)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.220

2.1.1.220

trnaimet

1-methyladenosine

nucleoside

mtases

two-subunit

thermus

exosome

polyadenylation

adomet

t-loop

polya

s-adenosylmethionine

n1-methylation

heterotetramer

homotetrameric

methionyl-trna

high-copy-number

eubacteria

methyltransferases

s-adenosyl-l-homocysteine

two-component

s-adenosyl-l-methionine-dependent

l-shaped

tpsic

trna-binding

hypomodified

drug development

Reaction

Synonyms

EC 2.1.1.36, Gcd10p, Gcd10p-Gcd14p, Gcd10pyGcd14p complex, Gcd14p, m1A58 MTase, m1A58 tRNA methyl-transferase, m1A58 tRNA methyltransferase, m1A58-methyltransferase, m1A58MTase, Rv2118c, Rv2118p, Trm6, TRM6-TRM61 holoenzyme, Trm61A, Trm61B, TRm61p, TRm6p, TrmI, tRNA (m1A58) methyltransferase, tRNA (m1A58) MTase, tRNA m(1)A58 methyltransferase, tRNA m1A58 methyltransferase, two component m1A58 tRNA methyl-transferase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.220 tRNA (adenine58-N1)-methyltransferase

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Results	in table
10024	AA Sequence
1	Application
8	Cloned(Commentary)
17	Cofactor
15	Crystallization (Commentary)
9	Disease/ Diagnostics
51	General Information
2	Inhibitors
5	KM Value [mM]
6	Localization
6	Molecular Weight [Da]
25	Natural Substrates/ Products (Substrates)
32	Organism
1	Pathway
15	PDB ID
6	pH Optimum
11	Protein Variants
8	Purification (Commentary)
4	Reaction
30	Reference
6	Source Tissue
45	Substrates and Products (Substrate)
31	Subunits
74	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]

Purification

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Purification on EC 2.1.1.220 - tRNA (adenine58-N1)-methyltransferase

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3 entries

coexpression of catalytic subunit Trm61p and non-catalytic subunit Trm6p in Saccharomyces cerevisiae, purification of the hTrm6p/hTrm61p complexes

Homo sapiens

Q96FX7; Q9UJA5

713498

recombinant C-terminally His-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography, cleavage of the tag by 3C protease, and gel filtration

Homo sapiens

Q96FX7

736642

recombinant enzyme from Escherichia coli strain Rosetta (DE3) by heat treatment at 70°C for 30 min, anion exchange and hydrophobic interaction chromatography, and dialysis, followed by cation exchange chromatography, gel filtration, and ultrafiltration

Aquifex aeolicus

O66653

736707

recombinant His-tagged TRM6 and TRM61 from Escherichia coli strain Rosetta (DE3) by nickel affinity chromatography and gel filtration

Saccharomyces cerevisiae

718504

recombinant wild-type and selenomethionine-labeled His-tagged subunits Trm6 and Trm61 from Escherichia coli by nickel affinity chromatography and gel filtration

Saccharomyces cerevisiae

P41814; P46959

758373