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2.1.1.221: tRNA (guanine9-N1)-methyltransferase

This is an abbreviated version!
For detailed information about tRNA (guanine9-N1)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.221

Reaction

S-adenosyl-L-methionine
+
guanine9 in tRNA
=
S-adenosyl-L-homocysteine
+
N1-methylguanine9 in tRNA

Synonyms

EC 2.1.1.31, hTRMT10A, m1G9 methyltransferase, m1G9 MTase, m1R9-specific TkTrm10, More, ScTrm10, SPOUT MTase, TK0422p, TkTrm10, Trm10, Trm10p (ambiguous), TRMT10A, Trmt10C, tRNA (guanine-N(1)-)-methyltransferase, tRNA m1G9 methyltransferase, tRNA m1G9 MTase, tRNA m1G9 SPOUT methyltransferase, tRNA m1R9 methyltransferase, tRNA(m1G9/m1A9)-methyltransferase, tRNA(m1G9/m1A9)MTase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.221 tRNA (guanine9-N1)-methyltransferase

Reference

Reference on EC 2.1.1.221 - tRNA (guanine9-N1)-methyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jackman, J.E.; Montange, R.K.; Malik, H.S.; Phizicky, E.M.
Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9
RNA
9
574-585
2003
Saccharomyces cerevisiae (Q12400), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kempenaers, M.; Roovers, M.; Oudjama, Y.; Tkaczuk, K.L.; Bujnicki, J.M.; Droogmans, L.
New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA
Nucleic Acids Res.
38
6533-6543
2010
Saccharomyces cerevisiae (Q12400), Thermococcus kodakarensis (Q5JD38)
Manually annotated by BRENDA team
Shao, Z.; Yan, W.; Peng, J.; Zuo, X.; Zou, Y.; Li, F.; Gong, D.; Ma, R.; Wu, J.; Shi, Y.; Zhang, Z.; Teng, M.; Li, X.; Gong, Q.
Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate
Nucleic Acids Res.
42
509-525
2014
Schizosaccharomyces pombe (O14214), Schizosaccharomyces pombe, Saccharomyces cerevisiae (Q12400), Saccharomyces cerevisiae, Schizosaccharomyces pombe 972 (O14214)
Manually annotated by BRENDA team
Igoillo-Esteve, M.; Genin, A.; Lambert, N.; Desir, J.; Pirson, I.; Abdulkarim, B.; Simonis, N.; Drielsma, A.; Marselli, L.; Marchetti, P.; Vanderhaeghen, P.; Eizirik, D.; Wuyts, W.; Julier, C.; Chakera, A.; Ellard, S.; Hattersley, A.; Abramowicz, M.; Cno
tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans
PLoS Genet.
9
e1003888
2013
Homo sapiens (Q8TBZ6), Homo sapiens
Manually annotated by BRENDA team
Swinehart, W.E.; Henderson, J.C.; Jackman, J.E.
Unexpected expansion of tRNA substrate recognition by the yeast m1G9 methyltransferase Trm10
RNA
19
1137-1146
2013
Saccharomyces cerevisiae (Q12400), Saccharomyces cerevisiae, Homo sapiens (Q8TBZ6)
Manually annotated by BRENDA team
Oerum, S.; Degut, C.; Barraud, P.; Tisne, C.
m1A Post-transcriptional modification in tRNAs
Biomolecules
7
20
2017
Schizosaccharomyces pombe (O14214), Saccharomyces cerevisiae (Q12400), Thermococcus kodakarensis (Q5JD38), Homo sapiens (Q7L0Y3), Homo sapiens (Q8TBZ6), Thermococcus kodakarensis JCM 12380 (Q5JD38), Schizosaccharomyces pombe ATCC 24843 (O14214), Schizosaccharomyces pombe 972 (O14214), Saccharomyces cerevisiae ATCC 204508 (Q12400), Thermococcus kodakarensis ATCC BAA-918 (Q5JD38)
Manually annotated by BRENDA team
Krishnamohan, A.; Dodbele, S.; Jackman, J.
Insights into catalytic and tRNA recognition mechanism of the dual-specific tRNA methyltransferase from Thermococcus kodakarensis
Genes (Basel)
10
100
2019
Thermococcus kodakarensis (Q5JD38), Thermococcus kodakarensis
Manually annotated by BRENDA team
Krishnamohan, A.; Jackman, J.E.
Mechanistic features of the atypical tRNA m1G9 SPOUT methyltransferase, Trm10
Nucleic Acids Res.
45
9019-9029
2017
Saccharomyces cerevisiae (Q12400), Saccharomyces cerevisiae, Homo sapiens (Q8TBZ6), Saccharomyces cerevisiae ATCC 204508 (Q12400)
Manually annotated by BRENDA team
Howell, N.; Jora, M.; Jepson, B.; Limbach, P.; Jackman, J.
Distinct substrate specificities of the human tRNA methyltransferases TRMT10A and TRMT10B
RNA
25
1366-1376
2019
Homo sapiens (Q8TBZ6), Homo sapiens
Manually annotated by BRENDA team