2.1.1.222: 2-polyprenyl-6-hydroxyphenol methylase
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For detailed information about 2-polyprenyl-6-hydroxyphenol methylase, go to the full flat file.
Reaction
Synonyms
2-polyprenyl-6-hydroxyphenyl methylase, 3-demethyl ubiquinone-9 3-methyltransferase, UbiG, UbiG methyltransferase, ubiquinone biosynthesis O-methyltransferase
ECTree
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General Information
General Information on EC 2.1.1.222 - 2-polyprenyl-6-hydroxyphenol methylase
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malfunction
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after 1 h of H2O2 treatment, the viability of the strain defective in ubiG is reduced 28fold compared to the corresponding wild-type. When treated with CuSO4, the viability of the the strain defective in ubiG (HW271), is reduced 4.4fold after 30 min compared to its isogenic wild-type
metabolism
physiological function
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the enzyme is required for both O-methylation steps in ubiquinone biosynthesis
metabolism
the enzyme catalyzes both of the two O-methyltransfer steps in CoQ10 biosynthesis
metabolism
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the enzyme is one of the key enzymes in the ubiquinone modification pathway
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the ubiG gene product is essential for growth on glycerol minimal medium
physiological function
the membrane-binding region of UbiG gates the entrance of methyl donor. When bound with liposome, UbiG displays an enhanced binding ability toward the methyl donor product S-adenosylhomocysteine