2.1.1.223: tRNA1Val (adenine37-N6)-methyltransferase
This is an abbreviated version!
For detailed information about tRNA1Val (adenine37-N6)-methyltransferase, go to the full flat file.
Reaction
Synonyms
YfiC
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.223 - tRNA1Val (adenine37-N6)-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + adenine37 in tRNA1(Val)
S-adenosyl-L-homocysteine + N6-methyladenine37 in tRNA1(Val)
S-adenosyl-L-homocysteine + N6-methyladenine37 in tRNA1(Val)
modification of adenine37 in the anticodon loop. The methylation of m6A in tRNA1 Val by YfiC has little influence on the cell growth under standard conditions, the yfiC gene confers a growth advantage under conditions of osmotic and oxidative stress
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S-adenosyl-L-methionine + adenine37 in tRNA1(Val)
S-adenosyl-L-homocysteine + N6-methyladenine37 in tRNA1(Val)
unmodified tRNA1(Val) with the anticodon cmo5UAC can be methylated by recombinant YfiC protein in vitro. YfiC methyltransferase can methylate tRNA1(Val), but none of other tRNAs tested (tRNA3(Arg), tRNA1(Glu), tRNA2(Val), tRNA5(Leu), tRNA5(Leu))
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