2.1.1.229: tRNA (carboxymethyluridine34-5-O)-methyltransferase
This is an abbreviated version!
For detailed information about tRNA (carboxymethyluridine34-5-O)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.229
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2.1.1.229
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wobble
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methyltransferases
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5-methoxycarbonylmethyluridine
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ribonucleotide
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anticodon
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gene-specific
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trnagluuuc
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translationally
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medicine
- 2.1.1.229
-
wobble
- methyltransferases
-
5-methoxycarbonylmethyluridine
- ribonucleotide
-
anticodon
-
gene-specific
- trnagluuuc
-
translationally
- medicine
Reaction
Synonyms
ABH8, ALKBH8, CmoA, MnmC, Trm9, Trm9-Trm112, Trm9p, TrmC, tRNA methyltransferase 9, YfcK, YML014w
ECTree
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Subunits
Subunits on EC 2.1.1.229 - tRNA (carboxymethyluridine34-5-O)-methyltransferase
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dimer
2 x 52500, gel filtration, mass spectrometry, and crystal structure analysis, 2 * 55600, about, sequence calculation. There are two molecules of CmoA present in the asymmetric unit, both molecules of CmoA contain the novel derivative S-adenosyl-S-carboxymethyl-L-homocysteine, the two molecules adopt the same conformation
heterodimer
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the enzyme is formed by catalytic subunit Trm9 and regulatory subunit Trm112
monomer
additional information
methyltransferase domain MnmC2 domain adopts the canonical class I methyltransferase fold
additional information
ALKBH8 and TRM112 form a functional tRNA methyltransferase complex (Trm112 is an accessory protein required for several methyltransferases)
additional information
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different catalytic subunits engage the same partner protein Trm112 to direct different chemical modifications on different residues