2.1.1.230: 23S rRNA (adenosine1067-2'-O)-methyltransferase
This is an abbreviated version!
For detailed information about 23S rRNA (adenosine1067-2'-O)-methyltransferase, go to the full flat file.
Reaction
Synonyms
EC 2.1.1.66, NHR, NHR protein, nosiheptide resistance methyltransferase, nosiheptide-resistance methyltransferase, thiostrepton resistance methyltransferase, thiostrepton-resistance methylase, thiostrepton-resistance methyltransferase, TSR
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Natural Substrates Products
Natural Substrates Products on EC 2.1.1.230 - 23S rRNA (adenosine1067-2'-O)-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + adenosine1067 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methyladenosine1067 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methyladenosine1067 in 23S rRNA
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S-adenosyl-L-methionine + adenosine1067 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methyladenosine1067 in 23S rRNA
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Streptomyces azureus is the producer of the peptide antibiotic thiostrepton. Thiostrepton inhibits protein synthesis by binding to the complex of 23S rRNA and protein L-11 which blocks processes associated with the GTP-hydrolysis center of the ribosome including the binding of guanine nucleotides, elongation factor proteins and tRNA. 23S rRNA (adenosine1067-2'-O)-methyltransferase confers resistance to tthiostrepton
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S-adenosyl-L-methionine + adenosine1067 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methyladenosine1067 in 23S rRNA
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the enzyme is involved in resistance to thiostrepton
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S-adenosyl-L-methionine + adenosine1067 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methyladenosine1067 in 23S rRNA
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the methylase enzyme, responsible for autoimmunity in the thiostrepton producer Streptomyces azureus, renders ribosomes completely resistant to thiostrepton
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S-adenosyl-L-methionine + adenosine1067 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methyladenosine1067 in 23S rRNA
enzyme Tsr uses the co-substrate AdoMet to methylate the 23 S rRNA, presumably prior to the assembly of the 50 S subunit as the L11 and proposed Tsr binding surfaces are overlapping
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